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Ism1 deficiency in mice exacerbates bleomycin-induced pulmonary fibrosis with enhanced cellular senescence and delayed fibrosis resolution
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Ism1 deficiency in mice exacerbates bleomycin-induced pulmonary fibrosis with enhanced cellular senescence and delayed fibrosis resolution

NEWS RELEASE 12-JUN-2024 Peer-Reviewed PublicationTSINGHUA UNIVERSITY PRESS IMAGE: DURING FIBROSIS PROGRESSION, ISM1-/- MICE EXHIBITED ENHANCED CELLULAR SENESCENCE IN THE ALVEOLAR TYPE II EPITHELIAL (AT2) CELLS WITH INCREASED RELEASE OF SENESCENCE ASSOCIATED PRO-INFLAMMATORY FACTORS WHICH LEAD TO ENHANCED IMMUNE CELL INFILTRATION, RELEASE OF PRO-FIBROTIC MEDIATORS PROMOTING THE ACTIVATION OF MYOFIBROBLASTS WITH EXCESSIVE COLLAGEN DEPOSITION, RESULTING IN...