KANAZAWA UNIVERSITY [Background] Nonalcoholic steatohepatitis (NASH) is associated with liver inflammation in patients with nonalcoholic fatty liver disease (NAFLD), and it can progress to liver fibrosis at an advanced stage, and also to hepatocellular carcinoma (HCC) and portal hypertension. Although liver fibrosis is considered to be accurately diagnosed via biopsy, noninvasive methods are preferable. Aldo-keto...
Tag: <span>Fibrosis</span>
Post
Unresolved injury, not fibrosis, contributes to cisplatin-induced CKD
by Julie Parry, Yale University Yale School of Medicine researchers have found that the progression of acute kidney injury to chronic kidney disease (CKD) caused by use of the chemotherapy drug cisplatin is due to unresolved injury and sustained activation of regulated necrosis pathways rather than fibrosis. The new study is highlighted on the cover of...
Post
Triclosan, often maligned, may have a good side — treating cystic fibrosis infections
Maybe you’ve had the experience of wading in a stream and struggling to keep your balance on the slick rocks or forgetting to brush your teeth in the morning and feeling a slimy coating in your mouth. These are examples of bacterial biofilms that are found anywhere a surface is exposed to bacteria in a...
Post
Mechanism of fibrosis development discovered
Idiopathic pulmonary fibrosis (IPF) is an incurable lung disease of unknown origin with limited treatment options. Research suggests that the signaling molecule WNT5A plays a key role in the pathogenic process. Now, a group of scientists from Helmholtz Center Munich, working with colleagues from the University of Denver, have taken a further step toward uncovering...
Post
Triclosan, often maligned, may have a good side—treating cystic fibrosis infections
July 11, 2018 by Chris Waters, The Conversation Maybe you’ve had the experience of wading in a stream and struggling to keep your balance on the slick rocks, or forgetting to brush your teeth in the morning and feeling a slimy coating in your mouth. These are examples of bacterial biofilms that are found anywhere a surface is...
Post
Metformin reverses established lung fibrosisc
Researchers at the University of Alabama at Birmingham have shown—for the first time—that established lung fibrosis can be reversed using a drug treatment that targets cell metabolism. Jaroslaw Zmijewski and Victor Thannickal. Credit: UAB This novel finding, reported in the journal Nature Medicine, is important because, despite significant advances to reveal the pathological mechanisms of persistent fibrosis,...
Post
Lipid-based nanoparticles enable improved therapy for cystic fibrosis patients
OREGON STATE UNIVERSITY PORTLAND, Ore. – Researchers at Oregon State University and Oregon Health & Science University are working on a treatment that holds great promise for improving the lives of cystic fibrosis patients. Cystic fibrosis is a progressive genetic disorder that results in persistent lung infection and afflicts 30,000 people in the U.S., with about 1,000...
Post
Researchers suppress fibrosis chemical signal to block haywire healing
Fibroblasts are cells within our connective tissue. They help maintain tissue scaffolding through production of collagen and other fibers. When pushed to action (induced) by TGF-beta, fibroblasts respond by producing stress fibers. In the …more An injured body always seeks to heal. But that process is far from simple. A host of cells organize to...
Post
Fibrosis reversed when ‘don’t eat me’ signal blocked, study finds
A chest radiograph of a patient with Idiopathic Pulmonary Fibrosis (IPF). Credit: Wikipedia/CC BY-SA 3.0 Researchers at the Stanford University School of Medicine have identified a pathway that, when mutated, drives fibrosis in many organs of the body. The pathway underlies what have been considered somewhat disparate conditions, including scleroderma, idiopathic pulmonary fibrosis, liver cirrhosis, kidney...