OSAKA UNIVERSITY IMAGE: Persistent infection and, potentially, cancer development are regulated by Helicobacter pylori (H. pylori) small RNA HPnc4160: H. pylori’s small RNA HPnc4160 suppresses the expression of messenger RNAs of pathogenic factors. When H. pylori infects the gastric mucosa, a mutation is introduced into a continuous thymidine (T) sequence (T-repeat) located upstream of the gene encoding HPnc4160. Because the...
