by Children’s Hospital of Philadelphia Milk-expanded T-cell clonotypes are enriched for interferon response gene signatures. Credit: Journal of Allergy and Clinical Immunology (2025). DOI: 10.1016/j.jaci.2025.01.008 A multi-institutional study led by researchers at Children’s Hospital of Philadelphia (CHOP) is the first to identify one of the allergens responsible for eosinophilic esophagitis (EoE), an inflammatory disease of the esophagus. This...
Tag: <span>food allergy</span>
Intestinal immune system gives new clues to mechanism behind food tolerance and allergies
by Katherine Fenz, Rockefeller University Credit: Pixabay/CC0 Public Domain With every bite of food we take, our intestinal immune system must make a big decision. Tasked with defending us from foreign pathogens, these exquisitely sensitive cells somehow distinguish friend from foe—destroying invaders while tolerating food and helpful bacteria. How the gut separates the good from the...
Could we cure or prevent food allergy by targeting an intestinal protein?
Peer-Reviewed Publication Boston Children’s Hospital FacebookXLinkedInWeChatBlueskyMessageWhatsAppEmail When is food simply nourishing and enjoyable, and when does it provoke an allergic reaction? The answer appears to lie in the balance of microbes that live in our intestine — and a specific protein secreted by intestinal goblet cells that influences that balance. Excess amounts of this protein,...
Injected Xolair therapy could prevent food allergies in kids
by Dennis Thompson A new treatment appears to reduce food allergies in children and teens, according to interim clinical trial results. A lab-made monoclonal antibody called omalizumab (Xolair) significantly increased the amounts of common foods that children could eat without sparking an allergic reaction, the U.S. National Institute of Allergy and Infectious Diseases (NIAID) reported....
Scientists identify unique subtype of eczema linked to food allergy
Atopic dermatitis, a common inflammatory skin condition also known as allergic eczema, affects nearly 20 percent of children, 30 percent of whom also have food allergies. Scientists have now found that children with both atopic dermatitis and food allergy have structural and molecular differences in the top layers of healthy-looking skin near the eczema lesions,...