MONASH UNIVERSITY IMAGE: THE IMAGE SHOWS A BRIGHTLY COLORED CANONICAL INTERACTION BETWEEN TCR AND PMHC WHICH IS CONDUCIVE TO SIGNAL TRANSDUCTION. THE FADED MIRROR IMAGE SHOWS A REVERSED TCR-PMHC INTERACTION WHICH IS UNABLE TO SUPPORT SIGNAL TRANSDUCTION AND THUS T CELL ACTIVATION. CREDIT: CREATED BY DR. ERICA TANDORI (ROSSJOHN LAB Monash University researchers have provided a fundamental...
by Monash University The canonical polarity of TCR–pMHC docking is essential for colocalization of CD3 and coreceptor-associated Lck and for productive TCR signaling. Schematic shows how canonical TCR–pMHC recognition colocalizes Lck and CD3, driving TCR-mediated signaling. By contrast, a reversed TCR–pMHC recognition polarity mislocalizes Lck and CD3, impeding signaling. Credit: Science (2021). Monash University researchers have provided a...
