by First Hospital of Jilin University (1) Degradation of mitochondria matrix, inner membrane and intermembrane oxidized or misfolded protein by mitochondrial proteases. (2) Ubiquitinated outer mitochondrial membrane proteins are extracted and degraded by the ubiquitin-proteasome system. (3) A portion of mitochondria budding off as mitochondria-derived vesicles and fuse with lysosomes for degradation. (4) Depolarized mitochondria...
by Keck School of Medicine of USC Credit: AI-generated imageIn one of the largest ever gene-environment interaction studies of red meat and colorectal cancer, which explored the impact of red meat consumption on a person’s cancer risk based on their genotype, researchers have identified two genetic markers that may help explain the association between the...
by Michigan State University IL-1β expression is increased in enteric glia after inflammation. Credit: Science Signaling (2023). DOI: 10.1126/scisignal.adg1668Researchers at Michigan State University may have discovered why visceral pain is so common in people who have experienced inflammation in their guts, including patients with irritable bowel syndrome, or IBS. Working with mouse models, MSU physiologists...
by Birgitte Svennevig, University of Southern Denmark Graphical Abstract. Credit: Journal of Hepatology (2023). DOI: 10.1016/j.jhep.2023.11.001Hormone therapy may be associated with menopause and fertility treatment, but now an SDU-led research team reports that certain intestinal hormones seem to have a beneficial effect on the processes behind the formation of scar tissue in the liver (liver...
by American Gastroenterological Association Credit: Nephron/WikipediaThe American Gastroenterological Association (AGA) has released a new evidence-based guideline recommending the use of blood and stool-based biomarkers to help manage Crohn’s disease, a type of inflammatory bowel disease (IBD). IBD is estimated to affect 2.74 million people in the U.S. The guideline was published today in Gastroenterology. Biomarkers...
by Columbia University Irving Medical Center An autoimmune reaction in mice to a protein associated with Parkinson’s disease damaged neurons in the GI tract, adding to evidence that the disease may get its start in the gut. Credit: David Sulzer Ask any neurologist: Parkinson’s disease is a brain disorder. The conspicuous symptoms of Parkinson’s disease—uncontrollable tremors,...
by Jackie Kruszewski, Virginia Commonwealth University A Virginia Commonwealth University researcher has published preliminary but striking evidence that shows the transplantation of gut bacteria may have implications for addiction disorders. Jasmohan Bajaj, M.D., a gastroenterologist and liver specialist, transplanted bacteria from another person’s stool into 10 volunteers with severe alcohol use disorder and cirrhosis. Nine...
by The Francis Crick Institute Researchers at the Francis Crick Institute have found two genes that regulate the differentiation of stem cells in the small intestine, offering valuable insight into how the body develops and maintains a healthy gut. Cells in the lining of the small intestine are replaced around every five days, the quickest...
by University of Michigan For children and young adults with Crohn’s disease, steroid-sparing therapies may help reduce the risk of developing a severe and common complication of the inflammatory bowel condition, a new study suggests. About one in three people with Crohn’s disease develop what’s known as a perianal fistula, which can be painful, difficult...
by Tracie White, Stanford University Medical Center Researchers found that, in addition to upper respiratory symptoms, a significant number of those sick with the new virus also suffered from loss of appetite, nausea, vomiting and diarrhea. The study, one of the earliest on U.S. patients with the coronavirus, was published online April 10 in Gastroenterology....
