September 17, 2024 by Nottingham Trent University Pharmacological pan-PHD inhibition induces Ucp1 expression in mouse and human adipocytes in vitro. Credit: Nature Communications (2024). DOI: 10.1038/s41467-024-51718-7Removing a specific gene from fat tissue could fool the body into speeding up metabolism and burning more calories, a new study has found. It is hoped that the research,...
JULY 12, 2024 by deCODE genetics LAG3 5′ UTR variant rs781745126-T creates a novel upstream open reading frame (uORF) and associates with lower plasma levels of LAG-3. Credit: Nature Communications (2024). DOI: 10.1038/s41467-024-50007-7Scientists at deCODE genetics have published a study in Nature Communications, comparing over 110 thousand patients with autoimmune thyroid disease (AITD) from Iceland,...
JULY 1, 2024 by Osaka University Molecular mechanism of senescence induced by osteoblast MEN1 deficiency SASP: senescence-associated secretory phenotype. Credit: Aging Cell (2024). DOI: 10.1111/acel.14254Osteoporosis—weakening of the bones with age—affects millions worldwide, and this figure is increasing annually as the global population ages. It is associated with the aging, or “senescence,” of bone cells, but...
Men with mutations in a particular gene are at greater risk of developing metastases after prostate cancer.News Published: May 17, 2024 | Original story from Aarhus University Credit: iStock. Finding out that cancer has spread is always unwelcome news. A study from Aarhus University has identified a gene that determines whether patients with prostate cancer...
by Wiley Credit: CC0 Public DomainNew research indicates that some age-related changes in gene and protein expression in the skeletal muscles of older individuals may be affected more by physical inactivity and chronic inflammation than primary aging, or intrinsic maturational processes. Physical inactivity and chronic inflammation are the most important drivers of secondary aging, or changes...
by Case Western Reserve University Representative human spinal cord tissue imaged at 4X objective for DAPI (blue), CD80 (red), and Iba1 (green) from an C9ORF72 ALS case and a non-ALS control. Scale bars represent 1000 µm or 100 µm as indicated. Credit: Science Translational Medicine (2024). DOI: 10.1126/scitranslmed.adg7895Researchers at Case Western Reserve University School of Medicine...
Research finds that antibiotic resistance genes are prevalent in the bacterium Campylobacter jejuni, a leading cause of food borne illness. The team finds that more than half of the C. jejuni, isolated from patients in Michigan, are genetically protected against at least one antibiotic used to fight bacterial infections. The team’s full report appears in...
By Bronwyn Thompson Evidence continues to mount that one of the world’s oddest creatures holds the key to unlocking good health in old age. Depositphotos They weigh about an ounce, spend their lives underground in sub-Saharan Africa and are unlikely to be making the shortlist for any cute animal calendars, but the naked mole-rat continues...
by Murdoch Children’s Research Institute Graphical representation of the findings from this study. Graphical summary of key findings from this study of sarcomere disorganization and SQSTM1 and MYOM1 mislocalization in ALPK3mut hPSC CMs. Credit: Nature Cardiovascular Research (2023). DOI: 10.1038/s44161-023-00219-9 Researchers have discovered how a gene that increases the risk of developing genetic heart disease functions, paving the way for new...
by Katrin Boes, Max Planck Society Wnt4 expression in islets. a Reporter constructs monitoring Wnt4 expression (Wnt4eGFPCre) and used for lineage tracing (Wnt4eGFPCre; mTmG). Expression pattern of Wnt4 revealed by mGFP immunostaining in Wnt4eGFPCre Tg+; mTmG Tg+ islets at E18.5 (b, c), P0 (d), P5 (e) and 8 weeks (f). DAPI marks the nucleus, Insulin β-cells, Glucagon α cells, as color-encoded....
