by Keck School of Medicine of USC Credit: CC0 Public DomainAs people age or become ill, their immune systems can become exhausted and less capable of fighting off viruses such as the flu or COVID-19. In a new mouse study published in Science Advances, researchers from the USC Stem Cell lab of Rong Lu describe how...
by Institute of Cancer Research Acute depletion of SET1/COMPASS core subunits reveals rapid turnover of H3K4me3. a, Schematic of the degron systems for the targeted degradation of DPY30 and RBBP5. b,c, Immunoblot analysis of DPY30, RBBP5 and H3K4me1–3 levels at the indicated times after treatment with 500 nM auxin (b) or 500 nM dTAG-13 (c). Washout, degron ligand was...
WEILL CORNELL MEDICINE IMAGE: IMAGE OF HUMAN BREAST CANCER CELLS SHOWING A) IMMUNOSUPPRESSIVE MACROPHAGES NEAR TUMOR CONNECTIVE TISSUE, AND B) IMMUNOSTIMULATORY MACROPHAGES NEAR TUMOR NESTS. CREDIT: NIR BEN CHETRIT. A new method can illuminate the identities and activities of cells throughout an organ or a tumor at unprecedented resolution, according to a study co-led by researchers at...
by Harry Perkins Institute of Medical Research Graphical abstract. Credit: Cell (2022). DOI: 10.1016/j.cell.2022.09.039 Australian scientists have developed a world-first map showing gene activity changes in diverse human brain cell types from pre-birth to adulthood. By having this map of normal brain cell development, researchers will now be able to identify altered states more accurately in neurological...
by University of Melbourne Figure 1. Gender-affirming hormone therapy model induced progressive change in blood DNA methylation. A Longitudinal GAHT model with blood collection at baseline (before hormone therapy), and 6 and 12 months after treatment. In total, samples from 13 transgender women and 13 transgender men were included in the study. B Number of differentially...
by UT Southwestern Medical Center Marked differences in gene activity were identified in the anterior portion of the hippocampus, which points downward toward the face, and the posterior, which points upward toward the back of the head. Credit: Melissa Logies A study of gene activity in the brain’s hippocampus, led by UT Southwestern researchers, has identified marked...
A team led by scientists at the Perelman School of Medicine at the University of Pennsylvania has illuminated the functions of mysterious structures in cells called “nuclear speckles,” showing that they can work in partnership with a key protein to enhance the activities of specific sets of genes. The discovery, which is published in Molecular...
