Tag: <span>Gene editing</span>

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Study in mice shows potential for gene-editing to tackle mitochondrial disorders

Defective mitochondria – the ‘batteries’ that power the cells of our bodies – could in future be repaired using gene-editing techniques. Scientists at the University of Cambridge have shown that it is possible to modify the mitochondrial genome in live mice, paving the way for new treatments for incurable mitochondrial disorders. Our cells contain mitochondria,...

‘Ghost’ viruses offer potentially better approach to gene editing
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‘Ghost’ viruses offer potentially better approach to gene editing

12 JAN 2022 BY ROBERT F. SERVICE Not every human disease can be tackled with a pill or shot. Some disorders would ideally be treated by delivering molecular payloads—like modified viruses carrying gene-editing tools—into defective cells, where they could rewrite target genes. Despite some early successes, researchers are still struggling to get this approach to...

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Potential New Gene Editing Tools Uncovered

Few developments have rocked the biotechnology world or generated as much buzz as the discovery of CRISPR-Cas systems, a breakthrough in gene editing recognized in 2020 with a Nobel Prize. But these systems that naturally occur in bacteria are limited because they can make only small tweaks to genes. In recent years, scientists discovered a...

Intellia, with first results, delivers a ‘landmark’ for CRISPR gene editing
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Intellia, with first results, delivers a ‘landmark’ for CRISPR gene editing

Ben Fidler Senior Editor  del Aguila III, Ernesto. (2018). “CRISPR Cas9” [Illustration]. Retrieved from Flickr. An infusion of an experimental CRISPR gene editing medicine has shown early promise as a treatment for a rare inherited condition, an encouraging finding that marks the latest, significant step forward for a technology awarded a Nobel prize last year. Treatment...

Gene editing produces all-male or all-female litters of mice
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Gene editing produces all-male or all-female litters of mice

3 DEC 2021 3:05 PM BY ELIZABETH PENNISI These mice have been genetically modified to parent single-sex litters. FRANCIS CRICK INSTITUTE In some farmers’ ideal world, cows would birth only females, sows would bear no boars, and chicks would all grow up to be hens. Such sex ratios would stop them from killing millions of...

Princeton-led study of DNA repair boosts prospects for gene editing technology
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Princeton-led study of DNA repair boosts prospects for gene editing technology

PRINCETON UNIVERSITY IMAGE: A NEW TOOL CALLED REPAIR-SEQ (MAGNIFYING GLASS) ALLOWS RESEARCHERS TO QUICKLY SEE HOW DIFFERENT GENES INVOLVED IN REPAIR OF DNA DAMAGE (AMBULANCES) AFFECT THE ACCURACY AND EFFICIENCY OF GENOME EDITING TECHNOLOGIES—IN THIS CASE, ONE THAT WORKS BY FIRST CAUSING A DOUBLE-STRANDED DNA BREAK. CREDIT: CAITLIN SEDWICK FOR PRINCETON UNIVERSITY The ability to...

Gene editing can turn storage fat cells into energy-burning fat cells
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Gene editing can turn storage fat cells into energy-burning fat cells

by  UT Southwestern Medical Center Lavanya Vishvanath, Senior Research Associate and Rana Gupta, Ph.D. in the research lab. Credit: UT Southwestern Medical Center A team of researchers at UT Southwestern Medical Center’s Touchstone Diabetes Center have successfully used CRISPR gene editing to turn fat cells normally used for storage into energy-burning cells. “It’s like flipping a switch. We removed the ‘brake’ on...

Beyond CRISPR: New class of gene-editing enzymes discovered
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Beyond CRISPR: New class of gene-editing enzymes discovered

By Michael Irving September 16, 2021 MIT researchers have discovered a new class of enzymes that could open a new range of genetic engineering tools like CRISPRlightsource/Depositphotos One of the most revolutionary discoveries of the century, the CRISPR gene-editing system is built on a bacterial defense mechanism that allows scientists to make precise edits to DNA. Now...

Researchers use gene editing to tackle facioscapulohumeral muscular dystrophy
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Researchers use gene editing to tackle facioscapulohumeral muscular dystrophy

by  Florida State University A diagram showing the muscles commonly involved in FSHD. Muscles most frequently involved are shown in pale purple and those with later involvement are shown in blue. Pathomechanisms and biomarkers in facioscapulohumeral muscular dystrophy: roles of DUX4 and PAX7. EMBO Mol Med (2021)e13695. Credit: Christopher R S Banerji Peter S Zammit, edited...