Tag: <span>Gene editing</span>

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Are we ready? Advances in CRISPR means the era of germline gene editing has arrived
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Are we ready? Advances in CRISPR means the era of germline gene editing has arrived

by Delthia Ricks , Medical Xpress Credit: CC0 Public Domain Quick, accurate, and easy-to-use, CRISPR-Cas9 has made genomic editing more efficient—but at the same time has made human germline editing much more feasible, erasing many of the ethical barriers erected to prevent scientists from editing the genes of heredity. “The ethical debate about what is...

Team reports how gene editing iPS cells can lead to a universal cancer immunotherapy product
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Team reports how gene editing iPS cells can lead to a universal cancer immunotherapy product

by  Kyoto University Cancer cell during cell division. Credit: National Institutes of Health Cancer immunotherapies have made the news for their startling effectiveness against certain cancers. However, current clinical therapies mainly use the patient’s own cells, limiting the number of patients who have access to this cure. CiRA Professor Shin Kaneko is developing iPS cells technology...

Gene editing expands to new types of immune cells
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Gene editing expands to new types of immune cells

by  Gladstone Institutes Alex Marson (left), Nevan Krogan (right), and their team fine-tuned CRISPR-Cas9 genome editing to work on human immune cells called monocytes. Credit: Michael Short/Gladstone Institutes In the decade since the advent of CRISPR-Cas9 gene editing, researchers have used the technology to delete or change genes in a growing number of cell types. Now,...

New gene editing strategies developed for Duchenne muscular dystrophy
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New gene editing strategies developed for Duchenne muscular dystrophy

by  UT Southwestern Medical Center In a mouse model and in human heart muscle cells, researchers used gene editing to modify specific DNA sequences and restore dystrophin production in mutant dystrophin genes. Credit: UT Southwestern Medical Center UT Southwestern scientists successfully employed a new type of gene therapy to treat mice with Duchenne muscular dystrophy (DMD),...

Intellia announced a new tool for gene editing
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Intellia announced a new tool for gene editing

Jason Mast Editor Alex­is Ko­mor David Liu, the Har­vard bio­chemist, was sit­ting in a meet­ing last week when his phone start­ed buzzing re­peat­ed­ly. Un­be­knownst to him, min­utes pri­or the CRISPR com­pa­ny In­tel­lia had fin­ished un­veil­ing their ap­proach to base edit­ing at a Cold Spring Har­bor Lab con­fer­ence. First pi­o­neered by Liu and his lab in...

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Gene editing enables researchers to correct mutation in muscle stem cells in DMD model

by University of Missouri Duchenne muscular dystrophy (DMD) is a rare but devastating genetic disorder that causes muscle loss and physical impairments. Researchers at the University of Missouri School of Medicine have shown in a mouse study that the powerful gene editing technique known as CRISPR may provide the means for lifelong correction of the...

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New CRISPR enzyme (Cas12b) makes for more precise gene-editing

The CRISPR gene-editing tool may be one of the most important medical breakthroughs in decades, but there’s still plenty of room for improvement. Although Cas9 has been the go-to enzyme for gene-editing, that doesn’t mean it’s necessarily the best option. Now a team of scientists, including the co-creator of CRISPR, has engineered a more precise...

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Scientists make first ever attempt at gene editing inside the body

New therapy will permanently alter DNA, with no way to alter mistakes editing may cause – but offers chance to tackle currently incurable metabolic diseases  Brian Madeux, 44, sits with his girlfriend Marcie Humphrey, waiting to receive the first human gene editing therapy.    Scientists have tried editing a gene inside the body for the...

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CRISPR toolbox gets two new molecular gadgets, boosting gene-editing

  The acronyms might not be quite as catchy as CRISPR — since, really, what is? — but what new genetic tools dubbed REPAIR and ABE lack in whimsy they promise to make up in utility. These advances announced Wednesday solve two of the problems hobbling CRISPR, the revolutionary genome-editing technique: that its idea of...

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This New Gene-Editing Technique Can Spot CRISPR’s Mistakes

IN BRIEF Scientists have developed a tool that can test an entire genome against a CRISPR molecule to predict potential errors and interactions. This will allow doctors to ensure treatments are safer and more effective. EDITING THE EDITOR The CRISPR gene-editing tool is already in use by scientists all over the world who are racing to cure...