by University College London Effect of MAPTRx on CSF concentrations of p-tau protein and tau/Aβ42. a, The mean percentage change from baseline in p-tau over time according to dose group. b, The mean percentage change from baseline in the ratio of t-tau to Aβ42 over time according to dose group. Error bars indicate the standard error of...
by Friedrich Miescher Institute for Biomedical Research By studying colonies of fission yeast (pictured), FMI researchers identified more than 20 mutations that enable RNA-mediated epigenetic gene silencing. Credit: Friedrich Miescher Institute for Biomedical Research Long considered ‘junk,” non-coding RNAs have emerged as important regulators of diverse cellular processes, including the silencing of genes. Working in yeast, researchers from the Bühler group have...
MASSACHUSETTS GENERAL HOSPITAL BOSTON – A long-running debate over how an important gene-silencing protein identifies its targets has been resolved by researchers at Massachusetts General Hospital (MGH). Their findings, reported in Nature Structural and Molecular Biology, also explain certain mysteries about the behavior of this protein, known as Polycomb repressive complex 2 (PRC2). PRC2 helps regulate whether genes...
