Tag: <span>Gene variant</span>

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Gene variant may underlie diabetes disparities: study
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Gene variant may underlie diabetes disparities: study

NEWS RELEASE 25-JUN-2024 Peer-Reviewed Publication VANDERBILT UNIVERSITY MEDICAL CENTER IMAGE: CO-CORRESPONDING AUTHOR AYUSH GIRI, PHD. CREDIT: VANDERBILT UNIVERSITY MEDICAL CENTER A genetic variation common in people of African ancestry is associated with an increased risk of complications from diabetes, including diabetic retinopathy, according to a report published June 25 in the journal Nature Medicine. The...

Common gene variant linked to COVID mortality
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Common gene variant linked to COVID mortality

by Rockefeller University Credit: Unsplash/CC0 Public Domain It may be the most baffling quirk of COVID: What manifests as minor, flu-like symptoms in some individuals spirals into severe disease, disability, and even death in others. A new paper published in Nature may explain the genetic underpinnings of this dichotomy. The researchers demonstrated that mice with gene variants...

Gene variant links trigger finger and carpal tunnel syndrome
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Gene variant links trigger finger and carpal tunnel syndrome

by University of Oxford Association between trigger finger and carpal tunnel syndrome. Data from UK Biobank. (A) Overlap between trigger finger and carpal tunnel syndrome in UK Biobank, annotated with the International Classification of Diseases (ICD)-10 codes and Office of Population Censuses and Surveys Classification of Surgical Operations and Procedures (OPCS) codes that were used...

Gene variant gives mice super-powered tendons for jumping and running
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Gene variant gives mice super-powered tendons for jumping and running

by The Scripps Research Institute Tendon-specific R2482H Piezo1 enhances jumping power and maximum running speed in mice. (A) Representative images of jumping in WT, Piezo1systemic-mut/+, Piezo1tendon-mut/+, and Piezo1muscle-mut/+mice. (B) Maximum jumping distance of each mouse. Male and female. n = 10 of each. Error bars represent SDs; *P < 0.05, **P < 0.01, ***P <...

Is it working? Scientists say gene variant indicates effectiveness of immunotherapy for allergies
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Is it working? Scientists say gene variant indicates effectiveness of immunotherapy for allergies

UNIVERSITY OF FUKUI IMAGE: ALMOST ONE THIRD OF THE POPULATION OF JAPAN IS ALLERGIC TO POLLEN FROM JAPANESE CEDARS. ALTHOUGH IMMUNOTHERAPY CAN GREATLY ALLEVIATE THE SYMPTOMS IN MOST PATIENTS AFTER PROLONGED TREATMENT, A CONSIDERABLE PERCENTAGE STILL DO NOT RESPOND FAVORABLY. CREDIT: THIS IMAGE WAS MARKED WITH A CC BY-SA 2.0 LICENSE. FOR REUSE, CREDIT THE...

Behind a good mutation: How a gene variant protects against Alzheimer’s
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Behind a good mutation: How a gene variant protects against Alzheimer’s

by University of California, Irvine Credit: CC0 Public Domain While the word “mutation” may conjure up alarming notions, a mutation in brain immune cells serves a positive role in protecting people against Alzheimer’s disease. Now University of California, Irvine biologists have discovered the mechanisms behind this crucial process. Their paper appears in the journal Alzheimer’s and...

Gene variant linked to unnecessary bone marrow biopsies in African Americans
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Gene variant linked to unnecessary bone marrow biopsies in African Americans

by  Vanderbilt University Medical Center From left, Scott Borinstein, MD, Ph.D., Jonathan Mosley, MD, Ph.D., and Sara Van Driest, MD, Ph.D., found that some healthy African Americans are having bone marrow biopsies they don’t need. Credit: Erin O. Smith/VUMC A gene variant that lowers white blood cell levels and is common in individuals with African ancestry...

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Gene variant protecting against Alzheimer’s disease decreases plasma beta-amyloid levels

New research from the University of Eastern Finland shows that the APP gene variant protecting against Alzheimer’s disease significantly decreases plasma beta-amyloid levels in a population cohort. This is a very significant discovery, as many on-going drug trials in the field of Alzheimer’s disease focus on decreasing beta-amyloid levels in the brain tissue. According to...