by Wiley Credit: CC0 Public DomainNew research indicates that some age-related changes in gene and protein expression in the skeletal muscles of older individuals may be affected more by physical inactivity and chronic inflammation than primary aging, or intrinsic maturational processes. Physical inactivity and chronic inflammation are the most important drivers of secondary aging, or changes...
by Case Western Reserve University Representative human spinal cord tissue imaged at 4X objective for DAPI (blue), CD80 (red), and Iba1 (green) from an C9ORF72 ALS case and a non-ALS control. Scale bars represent 1000 µm or 100 µm as indicated. Credit: Science Translational Medicine (2024). DOI: 10.1126/scitranslmed.adg7895Researchers at Case Western Reserve University School of Medicine...
Research finds that antibiotic resistance genes are prevalent in the bacterium Campylobacter jejuni, a leading cause of food borne illness. The team finds that more than half of the C. jejuni, isolated from patients in Michigan, are genetically protected against at least one antibiotic used to fight bacterial infections. The team’s full report appears in...
By Bronwyn Thompson Evidence continues to mount that one of the world’s oddest creatures holds the key to unlocking good health in old age. Depositphotos They weigh about an ounce, spend their lives underground in sub-Saharan Africa and are unlikely to be making the shortlist for any cute animal calendars, but the naked mole-rat continues...
by Murdoch Children’s Research Institute Graphical representation of the findings from this study. Graphical summary of key findings from this study of sarcomere disorganization and SQSTM1 and MYOM1 mislocalization in ALPK3mut hPSC CMs. Credit: Nature Cardiovascular Research (2023). DOI: 10.1038/s44161-023-00219-9 Researchers have discovered how a gene that increases the risk of developing genetic heart disease functions, paving the way for new...
by Katrin Boes, Max Planck Society Wnt4 expression in islets. a Reporter constructs monitoring Wnt4 expression (Wnt4eGFPCre) and used for lineage tracing (Wnt4eGFPCre; mTmG). Expression pattern of Wnt4 revealed by mGFP immunostaining in Wnt4eGFPCre Tg+; mTmG Tg+ islets at E18.5 (b, c), P0 (d), P5 (e) and 8 weeks (f). DAPI marks the nucleus, Insulin β-cells, Glucagon α cells, as color-encoded....
Tony Ho Tran Deputy Editor, Innovation & Tech Updated Nov. 03, 2022 2:23 PM ET / Published Nov. 03, 2022 2:00 PM ET Yuichiro Chino via Getty Autoimmune disorders cause the body’s own defense system to attack normal, healthy cells. They can also leave people vulnerable to diseases—resulting in more severe and deadly infections. But...
by Center for Genomic Regulation Image of a mouse pancreatic islet, regions in the pancreas that contain beta cells which secret insulin. The HASTER regulatory element has been knocked out in this mouse, resulting in changes to beta cell function that cause diabetes. Credit: Miguel A Garriga/CRG Researchers at the Centre for Genomic Regulation (CRG)...
by The Mount Sinai Hospital Recurrently dysregulated super-enhancers in CRC patients. a Study overview. Figure adapted from SMART Servier Medical Art, reproduced with permission, licensed under a Creative Commons Attribution 3.0 unported license. b PCA of H3K27ac signal at 2026 SEs in CRC (n = 15 independent tissue samples), normal mucosa (n = 15), crypts (n = 4), and FAP adenomas (n = 2). c, d GSEA between SE proximal...
by The Francis Crick Institute In vitro anticancer drug screen. a Volcano plots showing differences in IC50 values between RAS high and low CCLE cell lines. Drugs with enriched target annotations in the significant sensitive and resistant groups are highlighted (hypergeometric test) Drugs with an absolute log2 fold change >1 and fdr < 0.05 (linear model...
