Tony Ho Tran Deputy Editor, Innovation & Tech Updated Nov. 03, 2022 2:23 PM ET / Published Nov. 03, 2022 2:00 PM ET Yuichiro Chino via Getty Autoimmune disorders cause the body’s own defense system to attack normal, healthy cells. They can also leave people vulnerable to diseases—resulting in more severe and deadly infections. But...
by Center for Genomic Regulation Image of a mouse pancreatic islet, regions in the pancreas that contain beta cells which secret insulin. The HASTER regulatory element has been knocked out in this mouse, resulting in changes to beta cell function that cause diabetes. Credit: Miguel A Garriga/CRG Researchers at the Centre for Genomic Regulation (CRG)...
by The Mount Sinai Hospital Recurrently dysregulated super-enhancers in CRC patients. a Study overview. Figure adapted from SMART Servier Medical Art, reproduced with permission, licensed under a Creative Commons Attribution 3.0 unported license. b PCA of H3K27ac signal at 2026 SEs in CRC (n = 15 independent tissue samples), normal mucosa (n = 15), crypts (n = 4), and FAP adenomas (n = 2). c, d GSEA between SE proximal...
by The Francis Crick Institute In vitro anticancer drug screen. a Volcano plots showing differences in IC50 values between RAS high and low CCLE cell lines. Drugs with enriched target annotations in the significant sensitive and resistant groups are highlighted (hypergeometric test) Drugs with an absolute log2 fold change >1 and fdr < 0.05 (linear model...
by Institute of Molecular Biotechnology (IMBA) Graphical abstract. Credit: EMBO Molecular Medicine (2022). DOI: 10.15252/emmm.202215829 A multidisciplinary study led by Vanja Nagy (LBI-RUD/CeMM/Medical University of Vienna) and Josef Penninger (UBC/IMBA) characterized a novel gene, known as FIBCD1, to be likely causative of a new and rare neurodevelopmental disorder. Using data from two young patients with neurological symptoms,...
by University of Florida Jennifer Dungan. Credit: University of Florida When diagnostic tests for the heart were first created, scientists at the time did not fully consider that no two bodies are the same, especially between the sexes. According to University of Florida College of Nursing associate professor Jennifer Dungan, many of the current symptom...
UNIVERSITÉ DE GENÈVE IMAGE: BIOLOGISTS HAVE CREATED MUTANTS OF THE FER2 HOMOLOG IN MOUSE DOPAMINE NEURONS. CREDIT: (C) ADOBE STOCK Parkinson’s disease is a neurodegenerative disorder characterized by the destruction of a specific population of neurons: the dopaminergic neurons. The degeneration of these neurons prevents the transmission of signals controlling specific muscle movements and leads...
JANUARY 11, 2022 by Eric Hamilton, University of Wisconsin-Madison Fig. 1: Changes to the astrocyte translatome due to tau and amyloid pathology. A Schematic illustrating the crossing of MAPTP301S with the Aldh1l1_eGFP-RPL10a mouse. Astrocyte TRAP-seq performed on MAPTP301S vs. WT mice (both carrying the Aldh1l1_eGFP-RPL10a allele) at 3 months (B) and 5 months (C) in the spinal cord....
After you finish a milkshake or a bowl of guacamole, those dietary fats have a typical route through your body. New research from the laboratory of Dr. Natasza Kurpios, associate professor in the Department of Molecular Medicine in the Cornell College of Veterinary Medicine, has now revealed a key molecular mechanism that can send those fats on the...
Nonalcoholic fatty liver disease (NAFLD) affects almost a quarter of adults worldwide. Yale researchers have discovered a therapeutic target for the treatment of nonalcoholic fatty liver disease and liver insulin resistance in type 2 diabetes. The study appears in the issue of the Journal of Clinical Investigation. Liver disease is one of the leading causes of...
