by RIKEN Scientists from the RIKEN Center for Integrative Medical Science (IMS) and Keio University School of Medicine in Japan have used single-cell RNA analysis to find that supercentenarians—meaning people over the age of 110—have an excess of a type of immune cell called cytotoxic CD4 T-cells. Supercentenarians are a unique group of people. First,...
Tag: <span>Gene</span>
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Study finds key Alzheimer’s gene (APOE) acts differently in Caribbean Hispanics
Researcher says understanding genetic risk of a disease requires diverse gene pool UNIVERSITY OF WASHINGTON HEALTH SCIENCES/UW MEDICINE Researchers looking to unlock the mysteries of Alzheimer’s disease have revealed new insights from old variants. A gene called apolipoprotein E (APOE), long implicated in Alzheimer’s disease, has two variants that act differently among Caribbean Hispanics depending...
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New clues as to why mutations in the MYH9 gene cause broad spectrum of disorders in humans
Researchers use in vivo imaging to watch how cells move and generate forces inside living tissues, study sheds new light on how motor proteins generate forces inside living tissues and how genetic factors alter these forces to result in disease COLUMBIA UNIVERSITY SCHOOL OF ENGINEERING AND APPLIED SCIENCE New York, NY–October 28, 2019–Myosins are motor proteins that...
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NUS researchers use light from nanoparticles to intricately control biological processes
New nanoparticles can adjust the beating speed of heart cells by emitting different colours of light. Light from nanoparticle clusters was also able to activate anticancer drugs within cells NATIONAL UNIVERSITY OF SINGAPORE The biological technique of ‘optogenetics’ uses light to control cells within living tissues that have been genetically modified to be light-sensitive. However, deeply penetrating light is often needed to activate the...
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Competitor accuses 23andMe of ‘false negatives’ in cancer-gene testing
By SHARON BEGLEY when 23andMe received government permission in 2017 to sell health-related genetic testing, it came with several conditions, including that the company tell customers that its brand of testing can miss disease-causing variants. Now, in a study presented on Thursday at the annual meeting of the American Society of Human Genetics, a competitor has analyzed the likelihood of such...
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Scientists reveal novel oncogenic driver gene in human gastrointestinal stromal tumors
CHINESE ACADEMY OF SCIENCES HEADQUARTERS Sarcomas – cancers that arise from transformed mesenchymal cells (a type of connective tissue) – are quite deadly. Gastrointestinal stromal tumors (GISTs) are the most common human sarcoma and are initiated by activating mutations in the KIT receptor tyrosine kinase. Micro-GISTs are a smaller variation of clinical GISTs and are...
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Inflammation amps up neurite growth, gene expression involved in heat, cold sensitivity
by Tracey Peake, North Carolina State University Researchers from North Carolina State University have found that inflammation increases neuronal activity, gene expression and sensory nerve (neurite) outgrowth in neurons involved in thermal—but not physical- sensations in mice. The work sheds light on the role that inflammation-induced over expression of calcium channel genes may play in...
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Research discovers inhibitor to reverse toxic DUX4 effects
by University of Minnesota About one in 8,000 people have facioscapulohumeral muscular dystrophy, according to a 2014 study, which is relatively common in the world of genetic diseases. New University of Minnesota Medical School research identifies an inhibitor that protects cells from toxic effects associated with this disease in cells and mice. Facioscapulohumeral muscular dystrophy...
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How your genes affect the number on your scale
by Len Canter Could your genes be keeping you from losing weight? While you shouldn’t use a family tendency toward wide hips or an apple shape as an excuse to stray from a healthy diet, acceptance can help you reassess your personal ideal and make you happier with your body. Hundreds of genes have been...
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Mystery solved about the machines that move your genes
Date:September 2, 2019 Source: Simons Foundation Summary:Congestion causes the mass of tubes and motors that form chromosome-dividing spindles to move at full speed instead of slowing to a crawl, new research reveals. Fleets of microscopic machines toil away in your cells, carrying out critical biological tasks and keeping you alive. By combining theory and experiment, researchers have discovered the...