BAYLOR COLLEGE OF MEDICINE Predicting genes that can cause disease due to the production of truncated or altered proteins that take on a new or different function, rather than those that lose their function, is now possible thanks to an international team of researchers, including researchers from Baylor College of Medicine, that has developed a new analytical tool...
Tag: <span>Gene</span>
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Scientists discover how antiviral gene works
Finding could form the basis for potent new drugs ALBERT EINSTEIN COLLEGE OF MEDICINE BRONX, NY–(June 20, 2018)–It’s been known for years that humans and other mammals possess an antiviral gene called RSAD2 that prevents a remarkable range of viruses from multiplying. Now, researchers at Albert Einstein College of Medicine, part of Montefiore, have discovered the secret to the...
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Scientists discover new gene expression mechanism with possible role in human disease
UNC School of Medicine researchers, led by Brian Strahl, PhD, found surprising role for a protein called Spt6, which is crucial to the maintenance of proper messenger RNA levels in cells, a discovery that opens new research avenues and suggests a target UNIVERSITY OF NORTH CAROLINA HEALTH CARE CHAPEL HILL, NC – When cells grow and divide to...
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Gene signatures and biomarkers predict onset of rheumatoid arthritis in at-risk individuals
The results of two studies presented today at the Annual European Congress of Rheumatology (EULAR 2018) provide insight into molecular changes prior to the onset of arthritis which could inform future novel diagnostics and early therapeutic interventions. Rheumatoid arthritis (RA) is characterised by joint inflammation leading to destruction of bone and cartilage. Since structural joint damage is...
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Artificial gene defect reveals target to fight genetic disease
(Vienna, June 11, 2018) DNA Repair is essential for a healthy organism. In every day of our lives, tens of thousands of damages occur in the genetic material of our cells. Hence, it is not surprising that a broad variety of repair mechanisms developed in the course of evolution that enables cells to quickly react...
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Gene disruption signals cerebral palsy and autism link
University of Adelaide researchers has uncovered a genetic signal common to both cerebral palsy and autism. The finding comes from the first large-scale study of gene expression in children with cerebral palsy. The researchers, from the University’s Australian Collaborative Cerebral Palsy Research Group in the Robinson Research Institute, also showed common underlying molecular pathways in clinically diverse cerebral palsy. They say both...
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Gene therapy may help brain heal from stroke, other injuries
DALLAS – March 27, 2018 – Scientists have found a genetic trigger that may improve the brain’s ability to heal from a range of debilitating conditions, from strokes to concussions and spinal cord injuries. A new study in mice from UT Southwestern’s O’Donnell Brain Institute shows that turning on a gene inside cells called astrocytes...
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Complete genome sequence can be ID’d from amniotic fluid
(HealthDay)—The complete genome sequence of fetuses can be elucidated from amniotic fluid, according to a study published online March 15 in Clinical Chemistry. Qing Mao, from Complete Genomics Inc., in San Jose, Calif., and colleagues isolated cellular DNA and cell-free DNA (cfDNA) from the cell pellet of 31 amniocenteses and conducted sequencing to approximately 50× genome...