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Study reveals how migraine pain signals are generated—and blocked
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Study reveals how migraine pain signals are generated—and blocked

by New York University An illustration of the pain signaling pathway elicited by CGRP. CGRP activates the CGPR receptor on Schwann cells. The CGPR receptor traffics to endosomes, where sustained signaling results in the release of nitric oxide. Nitric oxide targets ion channel TRPA1 in Schwann cells, which excites the neuron and transmits pain signals...