MAY 31, 2024 by The Mount Sinai Hospital Schematic showing the structures of U4 and U6 RNAs, and the interactions between them. Mutations in the highlighted regions of U4 cause a neurodevelopmental disorder that affects tens of thousands. Credit: Lab of Ernest Turro, Ph.D., at Icahn Mount Sinai. Researchers at the Icahn School of Medicine...
by Nancy Fliesler, Children’s Hospital Boston Credit: CC0 Public Domain Despite it being very common, ADHD is often missed until a child reaches age seven or older. By that time, they have likely been struggling socially and in school. Could early genetic testing be part of the solution? Anne Arnett, Ph.D., in partnership with Ryan Doan,...
by St. Anna Children’s Cancer Research Institute Healthy T cells (left) and DOCK11-deficient T-cells (right) with visible nucleus (blue) and aktin-cytoskeleton (green). Credit: St. Anna Children’s Cancer Research Institute In the quest to find the origin of the puzzling symptoms in four children, researchers from St. Anna Children’s Cancer Research Institute, the CeMM Research Center...
by University of Pittsburgh Human chromosomes (gray) capped by telomeres (white). Credit: PD-NASA; PD-USGOV-NASA Scientists at the University of Pittsburgh School of Medicine have discovered the missing puzzle piece in the mystery of how melanoma tumors control their mortality. In a paper published in Science this week, Jonathan Alder, Ph.D. and his team describe how they discovered...
by Children’s Hospital Boston Credit: CC0 Public Domain Cerebral palsy, a non-progressing motor impairment that begins in early childhood, has widely been viewed as the result of oxygen deprivation during birth or other birth-related factors such as prematurity. While this is true for many children, new research from Boston Children’s Hospital finds that as many...
by Doug Dollemore, University of Utah Health Sciences Credit: Unsplash/CC0 Public Domain Every 11 minutes, an American dies by suicide. That’s 132 people a day or more than 48,000 annually. For those left behind, the haunting question is why. One emerging factor is family history. Perhaps the most famous example is Ernest Hemingway’s family. In addition to...
by Josh Barney, University of Virginia New University of Virginia research is revealing how genetic differences in the fat in men’s and women’s bodies affect the diseases each sex is likely to get. Researchers Mete Civelek, Warren Anderson and their collaborators have determined that differences in fat storage and formation in men and women strongly affect the activity of 162 different genes found...
Understanding of fibromuscular dysplasia (FMD), a rare blood vessel disease, is making the jump from the laboratory to the clinic with new findings of a genetic variant. Researchers found the mutation in a gene that is associated with classical Ehlers-Danlos Syndrome as well, in multifocal FMD. That means it could help clinicians understand whether a person...
by Bob Yirka , Medical Xpress Credit: Pixabay/CC0 Public Domain A team of researchers from Italy, the U.K. and the U.S. has isolated a number of immune cell-related genetic variants that may impact autoimmune conditions. In their paper published in the journal Nature Genetics, the group describes the host of tools and techniques they used to...
ETH researchers have discovered that they can use light-sensitive molecules to switch genetic networks on and off as required. Their finding gives rise to an easy method for dynamically controlling biotechnological substance production. Tetracycline (Tc), an antibiotic, and its derivative anhydrotetracycline (aTc) enjoy widespread use in biotechnology and synthetic biology. Both molecules influence gene expression....
