by University of Michigan Transcriptional modulation by the LE (Model A: epitope + IFN-γ, versus IFN-γ alone). a Heatmaps showing unsupervised clustering of upregulated (left, yellow) and downregulated (right, purple) DEGs for 65-79*LE, 65-79*SE and 65-79*PE. DEGs were selected based on a > 3-fold change for 65-79*LE. All depicted DEGs had a Padj < 0.05. b Venn diagrams showing comparison of DEGs for 65-79*LE,...
MICHIGAN MEDICINE – UNIVERSITY OF MICHIGAN Researchers at Michigan Medicine have uncovered the molecular mechanism that drives the disease-causing effects of the most common genetic risk factor for lupus, a study suggests. Systemic lupus erythematosus is a common, incurable autoimmune disease that affects millions of individuals worldwide, with a particularly high prevalence among women. A...
A study suggests that researchers at Michigan Medicine have uncovered the molecular mechanism that drives the disease-causing effects of the most common genetic risk factor for lupus. Systemic lupus erythematosus is a common, incurable autoimmune disease affecting millions worldwide, with a particularly high prevalence among women. A genetic variant, called HLA-DRB1*03:01, is the greatest risk factor...
INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) Identifying genetic risk factors for Alzheimer’s disease is essential if we are to improve our understanding and treatment of it. Progress in human genome analysis along with genome-wide association studies[ are now leading to major advances in the field. Researchers in Europe, the US and...
Sarah Sloat Mon, January 17, 2022, 9:03 AM·5 min read Scientists are piecing together why some people lose their sense of smell after contracting Covid-19. A study published Monday in the journal Nature Genetics identified a genetic risk factor associated with the loss of smell after a Covid infection, a discovery that brings experts closer to...
PET scan of a human brain with Alzheimer’s disease. Using human brain cells, scientists at the Gladstone Institutes discovered the cause of—and a potential solution for—the primary genetic risk factor for Alzheimer’s disease, a gene called apoE4. Having one copy of the apoE4 gene more than doubles a person’s likelihood of developing Alzheimer’s disease, and...
