by Todd Hollingshead, Brigham Young University Professor Mary Davis and student Will Brugger looked at data for 3,495 multiple sclerosis patients to find the connection between genetic risk and early onset. Credit: Jaren Wilkey/BYU Photo Anyone who has multiple sclerosis—or has a close friend with the disease—knows an MS diagnosis is the beginning of a...
A recent article published by researchers at the Institute of Genomics of the University of Tartu in the journal Human Reproduction described new links between polycystic ovary syndrome and genetics. Polycystic ovary syndrome is the most common endocrine disorder in women, characterised by irregular periods, high levels of androgen hormones and/or enlarged ovaries with many follicles containing...
by Newcastle University Fig. 1: Manhattan plots from acute myeloid leukemia meta-analysis of 4 genome-wide association studies. For each GWAS, association tests were performed for all AML cases and cytogenetically normal AML assuming an additive genetic model, with nominally significant principal components included in the analysis as covariates. Association summary statistics were combined for variants...
by Centenary Institute Graphical abstract. Credit: DOI: 10.1016/j.jhep.2021.10.005 An international research group led by the Centenary Institute has developed a world first genetic risk score (GRS) test able to identify patients at high-risk of developing alcohol-related cirrhosis. Cirrhosis (scarring of the liver) is responsible for approximately 300,000 deaths each year world-wide. In their study the researchers...
AARHUS UNIVERSITY Researchers from the Danish psychiatry research-project iPSYCH have contributed to identify 33 new genetic variants which, as it turns out, play a role in bipolar disorder. To achieve this, they have examined DNA profiles from 413,000 people. A number of scientific working groups are currently attempting to identify the genetic architecture underlying heritable and severe...
UNIVERSITY OF COPENHAGEN THE FACULTY OF HEALTH AND MEDICAL SCIENCES Over the past decade, scientists have identified hundreds of different genetic variants that increase a person’s risk of developing obesity. But a lot of work remains to understand how these variants translate into obesity. Now scientists at the University of Copenhagen have identified populations of...
The system allows researchers more control over DNA changes, potentially opening up conditions that have challenged gene-editors. Heidi Ledford For all the ease with which the wildly popular CRISPR–Cas9 gene-editing tool alters genomes, it’s still somewhat clunky and prone to errors and unintended effects. Now, a recently developed alternative offers greater control over genome edits — an advance...
The U.S. Food and Drug Administration has allowed marketing of 23andMe Personal Genome Service Genetic Health Risk (GHR) tests for 10 diseases or conditions. These are the first direct-to-consumer (DTC) tests authorized by the FDA that provide information on an individual’s genetic predisposition to certain medical diseases or conditions, which may help to make decisions...
The U.S. Food and Drug Administration today allowed marketing of 23andMe Personal Genome Service Genetic Health Risk (GHR) tests for 10 diseases or conditions. These are the first direct-to-consumer (DTC) tests authorized by the FDA that provide information on an individual’s genetic predisposition to certain medical diseases or conditions, which may help to make decisions...
