by Dana-Farber Cancer Institute Development of the BRCA-mt signature. UMAP representation of BRCA-mt and BRCA-wt samples from all evaluated cohorts without (a) and after (b) batch adjustment (N = 653). Volcano plots showing differentially expressed miRNAs between BRCA-mutated and wild-type samples without (c) and after (d) batch adjustment (N = 521); red markings represent miRNAs with P < 0.01 and FC > 1.5 or <0.66; purple markings denote ones...
In a paper published in Sciences Advances, researchers in the Department of Chemistry and the Department of Physics & Astronomy at the University of California, Irvine revealed new details about a key enzyme that makes DNA sequencing possible. The finding is a leap forward into the era of personalized medicine when doctors will be able to...
A new analysis finds that nearly three-quarters of 500 patients with advanced cancer could be referred to a potential targeted treatment based on the results of a comprehensive analysis of their tumor’s genetic landscape. The study suggests the value of so-called next generation sequencing, a sophisticated method of evaluating the DNA and RNA of a...
