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Study shows genetically modified pluripotent stem cells may evade immunological rejection after transplantation
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Study shows genetically modified pluripotent stem cells may evade immunological rejection after transplantation

by University of Arizona Generation of an HLA-I/II and MICA/B-deficient hESC line (A) Representation of the Cas9 editing strategy. Wild-type H1 hESCs were transfected with a Cas9 construct and up to three gRNAs at a time. gRNAs were for β2M, TAP1, CD74, CIITA, MICA, and MICB. Individual colonies were picked and sequenced to identify ones with...