by Jeff Hansen, University of Alabama at Birmingham Many heart diseases are linked to oxidative stress, an overabundance of reactive oxygen species. The body reacts to reduce oxidative stress—where the redox teeter-totter has gone too far up—through production of endogenous antioxidants that reduce the reactive oxygen species. This balancing act is called redox homeostasis. But...
Prostate cancer therapies have shown significant advances during the past decade, with multiple new therapies being introduced for patients with advanced disease. Now, the early results of a clinical trial published in the New England Journal of Medicine (NEJM) reveals for the first time that therapies based on tumor genetics – specifically DNA repair defects...
New research from the University of Sheffield into stem cells could help make regenerative medicine safer Regenerative medicine involves using pluripotent stem cells to repair damaged or diseased tissues in the body The new research has suggested ways to reduce the likelihood of mutations occurring in these cells when cultured. Research from the University of...
by Jake Miller, Harvard Medical School A team of researchers from Harvard Medical School, Brigham and Women’s Hospital, Socios En Salud, and the Broad Institute at Harvard and MIT report they have identified the single largest genetic contributor to height known to date. The findings, published May 13 in Nature, are based on an analysis...
by International & American Associations for Dental Research The Journal of Dental Research published today the results of a study that demonstrated that community water fluoridation is not associated with increased risk of osteosarcoma. More than sixty percent of the U.S. population have access to community water fluoridation, considered to be one of the most...
by Public Library of Science The reason why we sleep remains an unresolved question of the 21st century. Research by Sara Marie Ulv Larsen, Sebastian Camillo Holst and colleagues from the Neurobiology Research Unit at the University Hospital Copenhagen, published this week in the open access journal PLoS Biology, now shows that the depth of...
By Nick Lavars A growing body of evidence is forging a stronger and stronger connection between the onset of Parkinson’s disease and the gut. Scientists at Karolinska Institutet in Sweden and the University of North Carolina at Chapel Hill have thrown further weight behind this theory, with an investigation of cellular behavior in the nervous...
A new study is among the first to trace the molecular connections between genetics, the gut microbiome and memory in a mouse model bred to resemble the diversity of the human population. While tantalizing links between the gut microbiome and brain have previously been found, a team of researchers from two U.S. Department of Energy...
In a special report published today in the journal Blood, an international working group of experts in myelodysplastic syndromes (MDS) proposes – for the first time – the recognition of a distinct subtype of MDS based on the presence of a nonheritable genetic mutation that causes the disease. The mutation is found in approximately one...
by Queen Mary, University of London Acute angle closure glaucoma of the right eye (intraocular pressure was 42 in the right eye). Credit: James Heilman, MD/Wikipedia New research has identified a genetic mutation linked to a type of glaucoma, known as primary angle-closure glaucoma (PACG), which could open up new avenues for the early detection...
