Tag: <span>Genetics</span>

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A never-before-seen cell state may explain cancer’s ability to resist drugs

MEMORIAL SLOAN KETTERING CANCER CENTER Cancer’s knack for developing resistance to chemotherapy has long been a major obstacle to achieving lasting remissions or cures. While tumors may shrink soon after chemotherapy, many times they eventually grow back. Scientists once thought that unique genetic mutations in tumors underlay this drug resistance. But more and more, they...

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Non-invasive blood test can detect cancer four years before conventional diagnosis methods

by University of California – San Diego An international team of researchers has developed a non-invasive blood test that can detect whether an individual has one of five common types of cancers, four years before the condition can be diagnosed with current methods. The test detects stomach, esophageal, colorectal, lung and liver cancer. Called PanSeer,...

Study shows highly reproducible sex differences in aspects of human brain anatomy
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Study shows highly reproducible sex differences in aspects of human brain anatomy

by National Institutes of Health A scientific analysis of more than 2,000 brain scans found evidence for highly reproducible sex differences in the volume of certain regions in the human brain. This pattern of sex-based differences in brain volume corresponds with patterns of sex-chromosome gene expression observed in postmortem samples from the brain’s cortex, suggesting...

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Study shows genetic markers are useful in predicting osteoporotic fracture risk

Findings hold potential for cost savings while improving efficiency of screening HEBREW SENIORLIFE HINDA AND ARTHUR MARCUS INSTITUTE FOR AGING RESEARCH A new study shows that genetic pre-screening could reduce the number of screening tests needed to identify individuals at risk for osteoporotic fractures. Douglas P. Kiel, M.D., M.P.H.,director of the Musculoskeletal Research Center in...

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Loss of a co-twin linked to heightened psychiatric risk

New findings suggest twins who survive the loss of their co-twin face an elevated risk of psychiatric disorders in the short and longer term. ELIFE The death of a twin, especially earlier in life, can increase the risk of their surviving twin being diagnosed with a psychiatric disorder, finds a new study published today in...

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DRUG SHOWS PROMISE FOR FIGHTING RARE ALS

An experimental drug for a rare, inherited form of amyotrophic lateral sclerosis has shown promise in a phase 1/phase 2 clinical trial, researchers report. The trial indicated that the experimental drug, known as tofersen, shows evidence of safety that warrants further investigation and lowers levels of a disease-causing protein in people with a type of...

Nanoparticles for Large Gene Therapy to Cure Common Eye Diseases
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Nanoparticles for Large Gene Therapy to Cure Common Eye Diseases

MEDGADGET EDITORS GENETICS, NANOMEDICINE, OPHTHALMOLOGY Wet age-related macular degeneration and a number of other eye diseases, including congenital conditions, are related to mutated genes that result in blood vessel abnormalities. These can be treated with gene therapy, but delivering genetic material has proven to be difficult when dealing with large gene sequences that are common...

Lung cancer proteome builds on genetic findings to reveal therapeutic strategies
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Lung cancer proteome builds on genetic findings to reveal therapeutic strategies

by Tom Ulrich, Broad Institute of MIT and Harvard Lung cancer is the most commonly diagnosed cancer worldwide and the leading cause of cancer-related deaths, killing more per year than breast, colon, and prostate cancers combined. Over the years, studies of the lung cancer genome have fueled the development of drug therapies that target mutations...

Spatial mapping method pinpoints potential new therapeutic targets in lupus
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Spatial mapping method pinpoints potential new therapeutic targets in lupus

by Children’s Hospital of Philadelphia A team of researchers from Children’s Hospital of Philadelphia (CHOP) used a new method of pinpointing potential disease-causing changes in the genome to identify two new potential therapeutic targets for lupus, while also paving the way for more accurately identifying disease-causing variations in other autoimmune disorders. The findings were published...