JON HAMILTON This light micrograph from the brain of someone who died with Alzheimer’s disease shows the plaques and neurofibrillary tangles that are typical of the disease. A glitch that prevents healthy cell structures from transitioning from one phase to the next might contribute to the tangles, researchers say. Jose Luis Calvo/ Science Source The...
Findings could lead to new therapies for cancer, heart abnormalities UNIVERSITY OF COLORADO AT BOULDER Look deep inside our cells, and you’ll find that each has an identical genome -a complete set of genes that provides the instructions for our cells’ form and function. But if each blueprint is identical, why does an eye cell...
by Sheila Evans, University of Chicago Medical Center Many heritable immune diseases such as rheumatoid arthritis and blood-cell related traits derive from critical proteins not being made or not functioning correctly. But exactly how a person’s genes, the regulation of these genes and how the resulting proteins interact to cause disease is not widely understood....
Genomics carries great expectations: the power to help health-care providers assess and assist their patients in managing their individualized risks for common, serious medical conditions, such as cancer and heart disease. However, how to effectively meld genetic risk assessments into health care is a complex question. Several medical research institutions across the nation, including UW...
Stool microbes make a challenging diagnosis easier SCHEMATIC SHOWING HOW THE MICROBIOME SIGNATURE FROM STOOL SAMPLES CAN BE USED TO TEST FOR CIRRHOSIS. view more CREDIT: SALK INSTITUTE LA JOLLA–(July 1, 2020) Chronic liver disease represents a major global public health problem affecting an estimated 844 million people, according to the World Health Organization. It...
After examining the genes of more than 200,000 people all over the world who have type-2 diabetes, researchers from the Perelman School of Medicine at the University of Pennsylvania and the Veterans Health Administration’s (VHA) Corporal Michael J. Crescenz Veterans Affairs Medical Center (CMCVAMC) found hundreds of genetic variants never before linked to the disease....
by Dana-Farber Cancer Institute A novel liquid biopsy method can detect kidney cancers with high accuracy, including small, localized tumors which are often curable but for which no early detection method exists, say scientists from Dana-Farber Cancer Institute. The report in Nature Medicine suggests that if validated in larger trials and applied widely, the non-invasive...
by RIKEN A new study by researchers at the RIKEN Center for Integrative Medical Science in Japan reports differences in blood cell mutations between Japanese and European populations. The study found that these pre-clinical mutations were strongly associated with different types of cancers and can explain why Europeans have higher rates of chronic lymphocytic leukemia,...
by National Institute for Health Research BioResource A research program pioneering the use of whole-genome sequencing in the NHS has diagnosed hundreds of patients and discovered new genetic causes of disease. Whole genome sequencing is the technology used by the 100,000 Genomes Project, a service set up by the government which aims to introduce routine...
As COVID-19 restrictions loosen this summer, Canadians will spend more time outdoors and make the most of the sunshine. A new study from McGill University suggests why men may be more genetically prone to develop skin cancer. The research led by Professor Ian Watson of McGill’s Goodman Cancer Research Centre (GCRC), published in the journal...
