New research from Sharon Torigoe, biology faculty at Lewis & Clark College, is among the first to confirm an important characteristic of an enhancer for the Klf4 gene, which is important for establishing and maintaining naive-state pluripotent stem cells Peer-Reviewed Publication Lewis & Clark College image: Sharon Torigoe, assistant professor of biology at Lewis &...
Tag: <span>Genome</span>
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New study challenges longstanding assumption about the cause of the genome’s most common mutation
The PER-seq measured error signature of Pol ε P286R resembles the mutational spectrum and mutational signatures of POLEd and MMRd human cancers. Credit: Nature Genetics (2024). DOI: 10.1038/s41588-024-01945-x A Ludwig Cancer Research study has punctured a longstanding assumption about the source of the most common type of DNA mutation seen in the genome—one that contributes to many...
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‘Viral relicts’ in the genome could fuel neurodegeneration
by Marcus Neitzert, Deutsches Zentrum für Neurodegenerative Erkrankungen e.V. (DZNE) Different HERV glycoproteins increase intercellular protein aggregate spreading. a Experimental workflow. Donor HEK cells stably propagating aggregated NM-HA were transfected with a plasmid coding for V5-epitope tagged HERV-W Syncytin-1 or a plasmid coding for V5-epitope tagged HERV-K Env. Cells were subsequently cocultured with recipient HEK NM-GFPsol. b Western blot...
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Stresses and Hydrodynamics—Scientists Uncover New Organizing Principles of the Genome
A team of scientists, including mechanical engineers at the University of California San Diego, has uncovered the physical principles—a series of forces and hydrodynamic flows—that help ensure the proper functioning of life’s blueprint. Its discovery provides insights into the genome while potentially offering a new means to spot genomic aberrations linked to developmental disorders and...
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New report illustrates potential of precision genome editing in treating inherited retinal diseases
by University of California, Irvine Schematic representation of precision genome editing in treating inherited retinal diseases. Credit: PNAS In a new paper, University of California, Irvine researchers explain how precision genome editing agents have enabled precise gene correction and disease rescue in inherited retinal diseases (IRDs). The study, titled, “Precision genome editing in the eye,” was...
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CRISPR therapeutics can damage the genome
by Tel Aviv University Credit: Pixabay/CC0 Public Domain Researchers at Tel Aviv University warn that CRISPR therapeutics can damage the genome. They caution: “The CRISPR genome editing method is very effective, but not always safe. Sometimes cleaved chromosomes do not recover and genomic stability is compromised—which in the long run might promote cancer.” A new study...
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Blockchain not just for bitcoin. It can secure and store genomes too
by Bill Hathaway, Yale University Credit: Michael S. Helfenbein Blockchain is a digital technology that allows a secure and decentralized record of transactions that is increasingly used for everything from cryptocurrencies to artwork. But Yale researchers have found a new use for blockchain: they’ve leveraged the technology to give individuals control of their own genomes. Their...
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Genome-wide intricacies of cancer inhibitor untangled
by Will Doss, Northwestern University MYCi975 selectively affects MYC binding to promoters and target gene expression. (A) Heatmap representation of ChIP-seq signal at annotated promoters of MYCi975-sensitive sites (types 1, 2, and 3). (B) Log2(fold change) of genes for each type as calculated from differential gene expression analysis of DMSO- versus 48-hour MYCi975-treated 22Rv1 cells....
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It’s not all in their DNA: Cancer cells with the same genome can behave differently
by University of New South Wales The scientists observed which acute myeloid leukaemia cells are most likely to form cancerous tumours. Credit: Shutterstock For the first time, research has shown cancer cellswith the same genetic blueprint won’t necessarily behave in the same way, with serious implications for how we target them. A Peter Mac-led study...
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Genome “archipelago” as new model of how genomic information influences development and disease
A University at Buffalo team has developed a new model of how information in the genome is organized, called the novel genome archipelago model (GAM). The model provides new insights into how a multitude of interactions among genes may affect normal development as well as mutations that lead to cancer and other diseases. “GAM offers...