INSTITUTE FOR RESEARCH IN BIOMEDICINE (IRB BARCELONA) IMAGE: DNA METHYLATION HAS AN INTRINSIC EFFECT ON 3D GENOME STRUCTURE. CREDIT: IRB BARCELONA All the cells of an organism share the same DNA sequence, but their functions, shapes or even lifespans vary greatly. This happens because each cell “reads” different chapters of the genome, thus producing alternative sets of...
by The Mount Sinai Hospital Credit: CC0 Public Domain In the largest genetic study of bipolar disorder to date, researchers have identified 64 regions of the genome containing DNA variations that increase risk of bipolar disorder—more than double the number previously identified. The research team also found overlap in the genetic bases of bipolar disorder and other psychiatric disorders. Furthermore, the study supports...
by Children’s Hospital of Philadelphia Researchers from Children’s Hospital of Philadelphia (CHOP) have shown there may be key genetic differences in the causes of attention-deficit hyperactivity disorder (ADHD) between African Americans and people of European ancestry, which may play an important part in how patients of different ethnic backgrounds respond to treatments for this condition. The findings...
by Ludwig Maximilian University of Munich Retinitis pigmentosa is the most prevalent form of congenital blindness. Using a retinitis pigmentosa mouse model, LMU researchers have now shown that targeted activation of genes of similar function can compensate for the primary defect. As many as 40,000 people in Germany suffer from retinitis pigmentosa. This hereditary disorder...
INSTITUTE FOR RESEARCH IN BIOMEDICINE (IRB BARCELONA) ANALYSIS OF THE GENOMES OF 28,000 TUMORS FROM 66 TYPES OF CANCER. view more CREDIT: IRB BARCELONA Cancer is a group of diseases characterised by uncontrolled cell growth caused by mutations, and other alterations in the genome of cells. A tumour can present from hundreds to thousands of...
Singapore, 12 August 2020 – A Singapore team led by clinician-scientists and researchers from the National Cancer Centre Singapore (NCCS) discovered a genetic link to better predict treatment response for relapsed/refractory patients with natural- killer T-cell lymphoma (NKTCL), a highly aggressive form of blood cancer. The team performed whole-genome sequencing, to identify mutation in PD-L1...
by NIH/National Human Genome Research Institute The Encyclopedia of DNA Elements (ENCODE) Project is a worldwide effort to understand how the human genome functions. With the completion of its latest phase, the ENCODE Project has added millions of candidate DNA “switches” from the human and mouse genomes that appear to regulate when and where genes...
Six months of coronavirus: the mysteries scientists are still racing to solve From immunity to the role of genetics, Nature looks at five pressing questions about COVID-19 that researchers are tackling. In late December 2019, reports emerged of a mysterious pneumonia in Wuhan, China, a city of 11 million people in the southeastern province of...
by UT Southwestern Medical Center This graphic illustrates three-dimensional genome organization maps obtained form a representative metastatic cancer cell line. Credit: UT Southwestern Medical Center UT Southwestern researchers have identified vast webs of small snippets of the genome that interact with each other and with genes to promote prostate cancer. Their findings, published June 22...
by Research Institute of Molecular Pathology It has long been known that the acquired immune system can generate a vast antibody (immunoglobulin) repertoire by gene recombination in developing B-cells. However, it was not understood how the different immunoglobulin gene segments can meet each other in the three-dimensional space of a B-cell nucleus to undergo recombination,...
