It has been almost 20 years since the human genome was first sequenced, but researchers still know little about how the genome is folded up and organized within cells. In a paper to be published August 28 in the Journal of Cell Biology, researchers from the University of Illinois at Urbana-Champaign describe a new technique...
Tag: <span>Genome</span>
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New genome-editing strategy could lead to therapeutics
Researchers at UMass Medical School have developed a genome-editing strategy to correct disease-causing DNA mutations in mouse models of human genetic diseases, according to research published in the Aug. 18 edition of Nature Biotechnology. Credit: CC0 Public Domain First author Dan Wang, Ph.D., instructor in microbiology & physiological systems, together with co-corresponding authors Guangping Gao, Ph.D., the Penelope Booth...
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Sequence and organization of the human mitochondrial genome
Mitochondria can use fatty acids or carbohydrates to create the ATP our cells need for energy. However the ATP creation process from fat is more efficient and creates less free radicals as a by product. … Formitochondrial health, the answer appears to become fat-adapted and minimize our sugar intake. Mitochondria perform diverse yet interconnected functions, producing...
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First grand project from Genome Project-write (GP-write) looks to develop ultra-safe virus-resistant cells
The leadership of the GP-write project – Jef Boeke from NYU Langone Medical Centre (NY), George Church from Harvard Medical School (MA), Andrew Hessel from Autodesk Inc (CA) and Nancy J Kelley from New York Genome Center (NY, all USA) – have announced their project’s latest developments. Updating the goals of their seminal GP-write paper, published...
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Biochemists discover cause of genome editing failures with hyped CRISPR system
New study sheds light on biology of most-used Cas9 target UNIVERSITY OF ILLINOIS AT CHICAGO Researchers from the University of Illinois at Chicago are the first to describe why CRISPR gene editing sometimes fails to work, and how the process can be made to be much more efficient. IMAGE: UIC RESEARCHERS SHOW PERSISTENT CAS9 BINDING TO A DOUBLE STRAND...
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Recipe for perfect balance of breaks and repairs in our genome could help fight cancer
Scientists at the University of Sheffield have discovered what keeps the perfect balance of breaks and repairs in our DNA—something which could help improve the success of chemotherapy and combat neurodegeneration associated with aging. Our genome, where precious genetic information is stored, is challenged with thousands of breaks every day. Cells possess an army of...
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Genome editing method targets AIDS virus
By destroying the regulatory genes of the AIDS virus HIV-1 using the genome editing system CRISPR/Cas9, a Japanese research group has succeeded in blocking the production of HIV-1 by infected cells. Human immunodeficiency virus-1 (HIV-1) infection is a chronic disease affecting more than 35 million people worldwide. The infection can be controlled by antiretroviral therapy (ART), but...