by Wellcome Trust Sanger Institute Credit: Pixabay/CC0 Public Domain A pioneering genomic surveillance study has provided the clearest picture yet of the arms race between Streptococcus pneumoniae, the bacterium responsible for a range of illnesses such as pneumonia and meningitis, and the vaccines designed to protect against the most dominant types. A strain called GPSC10 was...
by The Mount Sinai Hospital Credit: Unsplash/CC0 Public Domain Both rare and commonly observed differences in the DNA letters strung along a person’s chromosomes can explain about a third of the risk for being diagnosed with obsessive-compulsive disorder (OCD), according to a new study led by scientists at the Icahn School of Medicine at Mount Sinai....
Using cellular genomics, Garvan-led researchers have uncovered new links between DNA variants and cell gene activity. Researchers led by the Garvan Institute of Medical Research have made a crucial step forward in the understanding of how our own DNA information influences our personal disease risk, thanks to cutting-edge cellular genomics technology. By analysing the gene activity of 64,018 individual skin...
This news or article is intended for readers with certain scientific or professional knowledge in the field. Telomeres are repeated DNA sequences at the ends of chromosomes. With each cell division a little telomere length is lost, and this is an important part of the countdown mechanism that limits replication of somatic cells. Somatic cells...
Toward an era where aging can be controlled KUMAMOTO UNIVERSITY THE HUMAN BODY AND THE CELLS THAT MAKE IT UP HAVE A “PROGRAM ” FOR AGING. IT IS THOUGHT THAT THERE IS AN ACCUMULATION OF SENESCENT CELLS IN TISSUES AND ORGANS… view more CREDIT: PROFESSOR MITSUYOSHI NAKAO Researchers from Kumamoto University in Japan have used...
UNIVERSITY OF MAINE Jared Talbot is part of a 32-member international research team that identified a gene that, when altered, can cause bent fingers and toes, clubfoot, scoliosis, and short stature. The team discovered that partial loss of the protein coding gene MYLPF (myosin light chain, phosphorylatable, fast skeletal muscle) results in a disorder called...
by Sanford Burnham Prebys Medical Discovery Institute Francesca Marassi, Ph.D., director of the Cancer, Molecules and Structures Program at Sanford Burnham Prebys Medical Discovery Institute and senior author of the study Credit: Sanford Burnham Prebys Medical Discovery Institute Scientists at Sanford Burnham Prebys Medical Discovery Institute have shown that the blood protein vitronectin is a...
by Jim Fessenden, University of Massachusetts Medical School UMass Medical School and Massachusetts General Hospital are the first to safely treat two research participants with a synthetic microRNA, delivered into the spinal fluid, designed to silence a human disease-causing gene. Details of the treatment, which targeted the mutant SOD1 gene that causes ALS, appear in...
Genomics carries great expectations: the power to help health-care providers assess and assist their patients in managing their individualized risks for common, serious medical conditions, such as cancer and heart disease. However, how to effectively meld genetic risk assessments into health care is a complex question. Several medical research institutions across the nation, including UW...
by Austrian Academy of Sciences Schematic outline of the study, which used genomic assays (RNA-seq, ATAC-seq, ChIPmentation, flow cytometry) to investigate epigenetic and transcription regulation in structural cells (endothelium, epithelium and fibroblast) from twelve mouse organs. Credit: Thomas Krausgruber / CeMM In a Nature paper, CeMM researchers report on the epigenetic and transcriptional regulation in...
