by Fred Hutchinson Cancer Center Graphical abstract. Credit: Cell Reports (2024). DOI: 10.1016/j.celrep.2024.113844Neuroscientists at Fred Hutchinson Cancer Center have found that an often-overlooked type of brain cell called glia has more of a role in brain function than previously thought. In the journal Cell Reports, Fred Hutch neuroscientist Aakanksha Singhvi, Ph.D., and her team report that...
by Tohoku University A 3D reconstructed synaptic structure capturing glial phagocytosis. A represents part of a 3D reconstructed Purkinje cell dendrite (yellow). Multiple spines are found at a high density along the dendrite. In many of the spines, aberrant protrusions were found (protrusions from the spine are colored in red). These protrusions were observed at...
Tauopathies like Alzheimer’s disease are characterized by the spread of tau aggregates through the brain. Tau is one of the few molecules in the body that can become altered in a way that encourages other copies of the same molecule to also alter, causing aggregates to form. These aggregates and their surrounding biochemistry are disruptive to cell function...
UNIVERSITY OF ALABAMA AT BIRMINGHAM IMAGE: PETER KING CREDIT: UAB BIRMINGHAM, Ala. – Neuroinflammation can worsen outcomes in stroke, traumatic brain injury or spinal cord injury, as well as accelerate neurodegenerative diseases like ALS, Parkinson’s or Alzheimer’s. This suggests that limiting neuroinflammation may represent a promising new approach to treat neurological diseases and neuropathic pain that...
Brain formation in worms goes awry when glial cell signaling is disrupted (right). As the very first neurons come together to form the brain, they need pointers to end up in the right places. Where do these directions come from? Rockefeller scientists have discovered that they originate from an unlikely source, revealing that the cells...
