by Pat Shellenbarger, Michigan State University Model depicting effects of OGM in GBM cells. Lactic acid accumulation from the Warburg effect activates GPR68, which suppresses ATF4 transcription. GPR68 inhibition by OGM induces ATF4 expression, which then increases CHAC1, leading to depletion of glutathione. This ultimately causes accumulation of toxic lipid peroxides, which triggers ferroptosis. Credit: Experimental...
by Brigham and Women’s Hospital Glioblastoma (histology slide). Credit: Wikipedia/CC BY-SA 3.0Glioblastoma (GBM), an aggressive brain cancer, is notoriously resistant to treatment, with recurrent GBM associated with survival of less than 10 months. Immunotherapies, which mobilize the body’s immune defenses against a cancer, have not been effective for GBM, in part because the tumor’s surrounding environment...
by Justin Jackson, Medical Xpress Experimental workflow. a, Schematic of study workflow. In human participants with dominant hemisphere gliomas, we applied subcortical high density electrocorticography during audiovisual speech initiation to assess tumor intrinsic neuronal circuit dynamics. Focusing on glioblastoma, we then assessed long-range functional connectivity using magnetoencephalography (MEG) imaginary coherence. b, Extra-operative language assessments were...
by University of Connecticut Design of PNAs and characterization of NPs. (A) Chemical structure of DNA, PNA, and serine-γ-PNA. (B) The sequence of oncomiR-21 and oncomiR-10b, where the underlined segment is the seed region. (C) PNAs used in the study. sγPNA-21 and sγPNA-10b are serine-γPNAs designed to bind the seed region of oncomiR-21 and oncomiR-10b, respectively....
In their new study, the researchers show how a modified peptide, in mice, helps a cancer drug pass through the blood-brain barrier, which is known to be extremely difficult to penetrate and thus serves as a massive hindrance to treating brain tumors. “We were not only able to get a drug into the brain, but...
by Medical College of Georgia at Augusta University Dr. Waaqo Daddacha. Credit: Michael Holahan, Augusta University In the tough war against glioblastoma, scientists are taking a cue from viruses on how to make the aggressive cancer more vulnerable to treatment. Their target is SAMHD1, a protein which can protect us from viral infections by destroying an essential...
UNIVERSITY OF TEXAS M. D. ANDERSON CANCER CENTER ABSTRACTS: 2006, 2511 CHICAGO ― Two studies led by The University of Texas MD Anderson Cancer Center that shed new light on the potential of the gut microbiome as a targetable biomarker to improve responses to immunotherapy were presented today at the 2022 American Society for Clinical Oncology (ASCO) Annual Meeting. The findings include...
by Joe Dangor, Mayo Clinic Glioblastoma multiform – MRT T2 axial. Credit: Hellerhoff/Wikimedia Commons, CC BY-SA 3.0 Glioblastoma is an aggressive cancer that can occur in the brain or spinal cord. It can occur at any age, but glioblastoma is more common in older adults. The average age of diagnosis is 64. Also known as glioblastoma multiforme, glioblastoma...
JANUARY 17, 2022 by University of Sussex Figure 1. Experimental pipeline. sEVs from GB patients and healthy volunteers’ blood samples were isolated through UC. The proteomic content of the sEVs were deciphered using mass spectrometry. Figure was created using BioRender.com. Credit: DOI: 10.3390/biomedicines10010125 Researchers at the University of Sussex are one step further to developing a...
by Medical College of Georgia at Augusta University Credit: CC0 Public Domain Inhaled CBD shrinks the size of the highly aggressive, lethal brain tumor glioblastoma in an animal model by reducing the essential support of its microenvironment, researchers report. “We saw a significant reduction in the size of the tumor and its microenvironment was different,”...
