September 30, 2024 by Brain Chemistry Labs Wyoming violets. Credit: Dr. Paul Alan Cox, Brain Chemistry LabsGlioblastoma is one of the most serious brain diseases known. More than 45% of brain cancers are gliomas. Only half of glioblastoma patients respond to the FDA-approved chemotherapy temozolomide (TMZ). Even for those patients, the cancer cells quickly evolve...
Tag: <span>glioblastoma</span>
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Scientists develop CAR-T cells to target glioblastoma while sparing healthy tissue
September 26, 2024 by University of Geneva Immunofluorescence staining of a representative human glioblastoma tissue section. In red, the PTPRZ1 markers, and in blue, the cell nuclei. (scale bar: 400 μm). Credit: Denis Migliorini – UNIGE/HUGScientists at UNIGE and HUG have developed CAR-T cells capable of targeting malignant gliomas while preserving healthy tissue. Glioblastoma is...
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B-cells hold promise for treating glioblastoma
September 23, 2024 by Olivia Dimmer, Northwestern University Quantitative analysis of BCR-seq data. Credit: Journal of Clinical Investigation (2024). DOI: 10.1172/JCI177384Harnessing the body’s B-cells to fight tumors may be a promising treatment for glioblastoma, according to a Northwestern Medicine study recently published in the Journal of Clinical Investigation. Glioblastoma, one of the most complex and...
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Researchers discover early, promising glioblastoma treatment
by Pat Shellenbarger, Michigan State University Model depicting effects of OGM in GBM cells. Lactic acid accumulation from the Warburg effect activates GPR68, which suppresses ATF4 transcription. GPR68 inhibition by OGM induces ATF4 expression, which then increases CHAC1, leading to depletion of glutathione. This ultimately causes accumulation of toxic lipid peroxides, which triggers ferroptosis. Credit: Experimental...
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Researchers design gene therapy that can effectively target glioblastoma
by Brigham and Women’s Hospital Glioblastoma (histology slide). Credit: Wikipedia/CC BY-SA 3.0Glioblastoma (GBM), an aggressive brain cancer, is notoriously resistant to treatment, with recurrent GBM associated with survival of less than 10 months. Immunotherapies, which mobilize the body’s immune defenses against a cancer, have not been effective for GBM, in part because the tumor’s surrounding environment...
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Glioblastoma found to hijack cognitive neural networks with thrombospondin-1
by Justin Jackson, Medical Xpress Experimental workflow. a, Schematic of study workflow. In human participants with dominant hemisphere gliomas, we applied subcortical high density electrocorticography during audiovisual speech initiation to assess tumor intrinsic neuronal circuit dynamics. Focusing on glioblastoma, we then assessed long-range functional connectivity using magnetoencephalography (MEG) imaginary coherence. b, Extra-operative language assessments were...
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Pharmacy researchers develop nanoparticle-based treatment for glioblastoma
by University of Connecticut Design of PNAs and characterization of NPs. (A) Chemical structure of DNA, PNA, and serine-γ-PNA. (B) The sequence of oncomiR-21 and oncomiR-10b, where the underlined segment is the seed region. (C) PNAs used in the study. sγPNA-21 and sγPNA-10b are serine-γPNAs designed to bind the seed region of oncomiR-21 and oncomiR-10b, respectively....
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DRUG CROSSES BLOOD-BRAIN BARRIER TO FIGHT GLIOBLASTOMA IN MICE
In their new study, the researchers show how a modified peptide, in mice, helps a cancer drug pass through the blood-brain barrier, which is known to be extremely difficult to penetrate and thus serves as a massive hindrance to treating brain tumors. “We were not only able to get a drug into the brain, but...
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Making glioblastoma more vulnerable to treatment
by Medical College of Georgia at Augusta University Dr. Waaqo Daddacha. Credit: Michael Holahan, Augusta University In the tough war against glioblastoma, scientists are taking a cue from viruses on how to make the aggressive cancer more vulnerable to treatment. Their target is SAMHD1, a protein which can protect us from viral infections by destroying an essential...
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Studies reveal new insights into gut microbiome impact on immunotherapy response in multiple cancers, including glioblastoma
UNIVERSITY OF TEXAS M. D. ANDERSON CANCER CENTER ABSTRACTS: 2006, 2511 CHICAGO ― Two studies led by The University of Texas MD Anderson Cancer Center that shed new light on the potential of the gut microbiome as a targetable biomarker to improve responses to immunotherapy were presented today at the 2022 American Society for Clinical Oncology (ASCO) Annual Meeting. The findings include...