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DNA nanotubes deliver therapeutics to glioblastoma tumors
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DNA nanotubes deliver therapeutics to glioblastoma tumors

by Gina Wadas,  Johns Hopkins University Fig. 1. Ten nucleotide ssDNA-amphiphiles form parallel G-quadruplexes and self-assemble into hollow nanotubes.(A) Chemical structures of the 10-nt ssDNA-amphiphiles. (B) CD spectra in Milli-Q water and PBS of the free 10-nt ssDNA and the ssDNA-amphiphiles. (C) Schematic representation of the nanotubes and the ssDNA-amphiphiles in the nanotubes, not drawn to...

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Areas of glioblastoma tumors correlate with separate subtypes of glioma stem cells

A new study published in the Oct. 9 issue of the journal Nature Medicine demonstrates, for the first time, that glioblastoma (GBM), the most common and most lethal brain tumor, is driven by two distinct subsets of cancer stem cells. Moreover, each subtype of glioma stem cells is driven by distinct transcriptional programs for growth and treatment...

October 10, 2017October 10, 2017by In Cancer