Acetazolamide increased sensitivity to treatment and enhanced survival in mice UNIVERSITY OF CHICAGO MEDICAL CENTER A drug used to treat altitude sickness — as well as glaucoma, epilepsy, heart failure and seizures — may also offer significant gains for patients with a fast-growing brain tumor known as glioblastoma, according to a study published July 4,...
Tag: <span>glioblastoma</span>
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Study finds mutation driving deadlier brain tumors and potential therapy to stop it
July 9, 2018, Perelman School of Medicine at the University of Pennsylvania A poorly understood mutation in the brain cancer glioblastoma (GBM) is now being implicated for the first time as the driver of rare but deadlier cases of the disease, a team of researchers from the Perelman School of Medicine at the University of Pennsylvania and the...
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Glioblastoma: A new treatment for this deadly brain tumor?
New research brings fresh hope of a new treatment for patients with glioblastoma, after identifying a way to halt the growth of this life-threatening brain tumor. Researchers may have found a way to halt the growth of deadly glioblastoma brain tumors. Scientists from the Massachusetts Institute of Technology (MIT) in Boston have identified the mechanism by...
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Drug combo doesn’t lengthen glioblastoma survival
(HealthDay)—In patients with progressive glioblastoma, treatment with lomustine plus bevacizumab does not confer a survival advantage over treatment with lomustine alone, according to a study published online Nov. 15 in the New England Journal of Medicine. Wolfgang Wick, M.D., from the University of Heidelberg in Germany, and colleagues randomly assigned patients with progression after chemoradiation (2-to-1...
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Onalespib could be an effective treatment for glioblastoma, preclinical studies show
The targeted therapy onalespib has shown effectiveness in preclinical studies of glioblastoma by researchers at The Ohio State University Comprehensive Cancer Center — Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC — James). Onalespib is designed to inhibit a molecule called HSP90. The molecule helps newly made protein molecules fold into...
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Grappling with cancers like John McCain’s glioblastoma that break all the rules
Arizona Sen. John McCain’s recent diagnosis of the hard-to-treat cancer glioblastoma stands in contrast to recent media reports that paint an optimistic picture of cancer treatment in America. A sampling of headlines includes “Cancer survival rates at all-time high” and “Cancer death rates continue to decrease in the United States.” Driving much of the progress...
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Building a better blood-brain barrier model
Delivering drugs to the brain is no easy task. The blood-brain barrier -a protective sheath of tissue that shields the brain from harmful chemicals and invaders – cannot be penetrated by most therapeutics that are injected into a person’s blood stream. But for treating diseases of the central nervous system and cancers such as glioblastoma,...
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Brain cancer study reveals therapy clues
Researchers have pinpointed two key molecules that drive the growth of an aggressive type of adult brain cancer. The findings shed light on the mechanisms that underpin brain cancer progression and could eventually reveal targets for the development of much-needed therapies, researchers say. Lab tests Scientists conducted lab tests on tumour cells from patients with glioblastoma, a rare but...
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Results of glioblastoma clinical trial show safety and clinical benefit of CAR T cell therapy
Glioblastoma is the most common brain tumor in humans and also one of the most difficult cancers to treat; patients with this type of cancer only survive about one year from time of diagnosis. Researchers at Baylor College of Medicine, Texas Children’s Cancer Center, and the Center for Cell and Gene Therapy at Baylor, Texas...
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Stem cells beat the clock for brain cancer
New research has shown that human skin cells can be transformed into stem cells, and used to hunt down brain cancer Glioblastoma is an aggressive form of brain cancer that kills most patients within two years of diagnosis. In tests on mice last year, a team at the University of North Carolina at Chapel Hill...