Large randomized clinical trials can uncover biomarkers that indicate which cancer treatments are likely to work best for individual patients. But it’s been challenging to find these biomarkers in rarer cancers where such robust data aren’t available. Using a new approach that combines data from human tumors grown in mice with data from The Cancer Genome Atlas, a team led...
Tag: <span>glioblastoma</span>
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Glioblastoma Pathway Signatures, Treatment Responses Differ Between Male, Female Patients
NEW YORK (GenomeWeb) – A team led by researchers at Washington University has identified molecular features that differ between glioblastoma (GBM) brain tumors of males and females and may be used to better tailor treatment. As they reported online yesterday in Science Translational Medicine, the researchers used available transcriptome data from the Cancer Genome Atlas...
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Scientists solve century-old neuroscience mystery; answers may lead to epilepsy treatment
Scientists at the Virginia Tech Carilion Research Institute have solved a 125-year-old mystery of the brain, and, in the process, uncovered a potential treatment for acquired epilepsy. Since 1893, scientists have known about enigmatic structures called perineuronal nets wrapped around neurons, but the function of the nets remained elusive. IMAGE: A RESEARCH TEAM LED BY HARALD SONTHEIMER...
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Altitude sickness drug appears to slow progression of glioblastoma
Acetazolamide increased sensitivity to treatment and enhanced survival in mice UNIVERSITY OF CHICAGO MEDICAL CENTER A drug used to treat altitude sickness — as well as glaucoma, epilepsy, heart failure and seizures — may also offer significant gains for patients with a fast-growing brain tumor known as glioblastoma, according to a study published July 4,...
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Study finds mutation driving deadlier brain tumors and potential therapy to stop it
July 9, 2018, Perelman School of Medicine at the University of Pennsylvania A poorly understood mutation in the brain cancer glioblastoma (GBM) is now being implicated for the first time as the driver of rare but deadlier cases of the disease, a team of researchers from the Perelman School of Medicine at the University of Pennsylvania and the...
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Glioblastoma: A new treatment for this deadly brain tumor?
New research brings fresh hope of a new treatment for patients with glioblastoma, after identifying a way to halt the growth of this life-threatening brain tumor. Researchers may have found a way to halt the growth of deadly glioblastoma brain tumors. Scientists from the Massachusetts Institute of Technology (MIT) in Boston have identified the mechanism by...
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Drug combo doesn’t lengthen glioblastoma survival
(HealthDay)—In patients with progressive glioblastoma, treatment with lomustine plus bevacizumab does not confer a survival advantage over treatment with lomustine alone, according to a study published online Nov. 15 in the New England Journal of Medicine. Wolfgang Wick, M.D., from the University of Heidelberg in Germany, and colleagues randomly assigned patients with progression after chemoradiation (2-to-1...
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Onalespib could be an effective treatment for glioblastoma, preclinical studies show
The targeted therapy onalespib has shown effectiveness in preclinical studies of glioblastoma by researchers at The Ohio State University Comprehensive Cancer Center — Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC — James). Onalespib is designed to inhibit a molecule called HSP90. The molecule helps newly made protein molecules fold into...
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Grappling with cancers like John McCain’s glioblastoma that break all the rules
Arizona Sen. John McCain’s recent diagnosis of the hard-to-treat cancer glioblastoma stands in contrast to recent media reports that paint an optimistic picture of cancer treatment in America. A sampling of headlines includes “Cancer survival rates at all-time high” and “Cancer death rates continue to decrease in the United States.” Driving much of the progress...
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Building a better blood-brain barrier model
Delivering drugs to the brain is no easy task. The blood-brain barrier -a protective sheath of tissue that shields the brain from harmful chemicals and invaders – cannot be penetrated by most therapeutics that are injected into a person’s blood stream. But for treating diseases of the central nervous system and cancers such as glioblastoma,...