by Johns Hopkins University School of Medicine Schematic showing DRP-104’s bio-activation to DON in tumor and bio-inactivation to an inert metabolite in GI tissues. Credit: Jennifer E. Fairman, CMI, FAMI, Department of Art as Applied to Medicine Johns Hopkins Medicine researchers have revamped an anti-cancer drug to better target cancer cells and leave healthy tissues...
by VIB (the Flanders Institute for Biotechnology) Representative images of embryonic myosin heavy chain (eMyHC) expression in TA muscle 6 days after CTX injury. A team headed by Prof. Massimiliano Mazzone (VIB-KU Leuven Center for Cancer Biology), in collaboration with Dr. Emanuele Berardi and Dr. Min Shang, revealed a new metabolic dialogue between inflammatory cells and...
by Brita Belli, Yale University Researchers at Yale have identified a molecule that plays a key role in the body’s inflammatory response to overeating, which can lead to obesity, diabetes, and other metabolic diseases. The finding suggests that the molecule could be a promising therapeutic target to control this inflammation and keep metabolic diseases in...
by Emily Packer, Ecole Polytechnique Federale de Lausanne Blocking a pair of sugar-transporting proteins may be a useful treatment approach for lung cancer, suggests a new study in mice and human cells published today in eLife. Cancer cells use a lot of sugar to fuel their rapid growth and spread. This has led scientists to...
They say it’s hell getting old. And while I’m not sure who “they” are, even though there are a lot of wonderful aspects of life in our later years, I can tell you that getting older is not without its fair share of challenges as well. One of them is a phenomenon called sarcopenia. Like osteoporosis...
Scientists at the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA have discovered that squamous cell skin cancers do not require increased glucose to power their development and growth, contrary to a long-held belief about cancer metabolism. Image shows squamous cell skin cancer tumors with lactate production (a byproduct of glucose...
UNIVERSITY OF COPENHAGEN THE FACULTY OF HEALTH AND MEDICAL SCIENCES Researchers find important new piece in the Huntington’s disease puzzle In a new study, researchers from the University of Copenhagen have discovered a hitherto unknown error in the transport of glutamine between astrocytes and neurons in the brain of mice with Huntington’s disease. At the same time, it...
Scientists have discovered an essential mechanism in the spread of cancer. A team led by professor Massimiliano Mazzone (VIB-KU Leuven) and professor Alessandra Castegna (University of Bari) has demonstrated a way to alter the metabolism of macrophages, a particular type of white blood cell often responsible for supporting tumor growth. They found that reducing the...
Researchers have discovered the mechanism of this control, with implications for developmental biology, the immune response and cancer dysregulation The 200 different types of cells in the body all start with the same DNA genome. To differentiate into families of bone cells, muscle cells, blood cells, neurons and the rest, differing gene programs have to...
Most cancers require large amounts of glutamine for rapid growth and there are numerous studies indicating that they cannot survive without it, a phenomenon termed ad “glutamine addiction”. This led to the idea that preventing tumors from glutamine uptake could be a potential therapeutic strategy. Researchers from Berlin and Wurzburg, Germany conclude that glutamine deprivation...
