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‘Goldilocks’ treatment window could lead to cancer therapy without harmful side effects
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‘Goldilocks’ treatment window could lead to cancer therapy without harmful side effects

by Walter and Eliza Hall Institute of Medical Research Learning the rules for programming self-associating membrane proteins (MPs). (a) Rosetta fold, dock, and design uses backbone fragments from natural MPs to construct symmetric, de novo architectures and an MP energy function (Weinstein et al., 2019) to optimize the amino acid sequence. (b) Round 1 designs...