by Massachusetts Eye and Ear Infirmary VPA/MYC synergistically reprogram adult SCs for HC-like cell regeneration. (A) A schematic diagram illustrating the experimental procedure of the cultured adult cochleae treated transiently by Dox to induce Myc and VPA to activate NICD (DV) and HC-like cell induction by Ad.Atoh1. (B and C) Vehicle (sterile water)/Ad.Atoh1 or Dox/VPA/Ad.Atoh1-treated adult (P30) rtTA/tet-Myc/Atoh1-GFP mice cochleae were labeled with MYO7A/GFP....
Tag: <span>hair cells</span>
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Study uncovers hair cell loss as underlying cause of age-related hearing loss
by Massachusetts Eye and Ear Infirmary In a new study of human ear tissues, hearing scientists have demonstrated that age-related hearing loss, also called presbycusis, is mainly caused by damage to hair cells, the sensory cells in the inner ear that transform sound-induced vibrations into the electrical signals that are relayed to the brain by...