Tag: <span>heart failure</span>

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Biomarker blood test could reveal high risk heart patients in need of treatment

UT SOUTHWESTERN MEDICAL CENTER DALLAS – Nov. 11, 2019 – Without occasionally looking under the hood, it’s difficult to predict whether expensive car repairs lie ahead. In a similar way, preventive cardiologists are looking for ways to detect early stage heart disease in people who aren’t currently in treatment. Preventive cardiology researchers at UT Southwestern Medical Center believe...

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A kinase identified as possible target to treat heart failure

New study identifies HIPK2 as a novel regulator of heart failure progression UNIVERSITY OF ALABAMA AT BIRMINGHAM BIRMINGHAM, Ala. – An unexplored kinase in heart muscle cells may be a good target to treat heart failure, a disease that is only incrementally delayed by existing therapies. Failing human hearts showed reduced amounts of this kinase, and preclinical experiments showed that restoring the amount of this kinase in...

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Research improves understanding of mechanism of atrial fibrillation

by Baylor College of Medicine Atrial fibrillation is the most common heart arrhythmia in humans. This condition increases the risk of heart failure, stroke, dementia and death, and current treatments have suboptimal efficacy and carry side effects. Looking to identify clues that might lead to better treatments, a group headed by researchers at Baylor College...

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Delays in heart failure diagnosis for chronically ill people leads to much worse outcomes

by University of Leicester More people are being diagnosed in hospital with heart failure than in the community because vital heart failure symptoms are being missed. A major Leicester Diabetes Centre study, which has looked at data collected across a 20-year period, has found that over 70 percent of people are not being diagnosed with...

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Atrial fibrillation common and incurable, but controllable

by Scott Gilbert,  Pennsylvania State University One of the most common problems cardiologists handle is atrial fibrillation, also called AFib or AF. AFib is an abnormal or irregular heartbeat that can lead to blood clots, stroke, heart failure and other heart-related complications. As many as 6 million people in the United States and 33 million people...

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The Intestine Responds to Heart Failure by Enhanced Mitochondrial Fusion through Glucagon-like Peptide-1 Signaling

Aims Glucagon-like peptide-1 (GLP-1) is a neuroendocrine hormone secreted by the intestine. Its receptor (GLP-1R) is expressed in various organs, including the heart. However, the dynamics and function of the GLP-1 signal in heart failure remains unclear. We investigated the impact of the cardio-intestinal association on hypertensive heart failure using miglitol, an α-glucosidase inhibitor known...

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Researchers discover how to treat diastolic heart failure

Research out of University Minnesota Medical School and published in the Journal of Clinical Investigation Insight uncovers what causes diastolic heart failure and how it can be treated. In the article, “Magnesium supplementation improves diabetic mitochondrial and cardiac diastolic function,” author Samuel Dudley, MD, Ph.D., Academic Chief of Cardiology at the University of Minnesota Medical...

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For older adults with heart failure: Can taking too many medications reduce abilities?

As we age, we tend to develop a number of chronic health conditions and concerns. Often, managing health problems can mean that older adults may take many different medications. When older adults take five or more medicines (a scenario health experts call “polypharmacy”, it can increase the risk of harmful side effects. Polypharmacy can contribute...