This paper is interesting as a first step on the way to further research into compensatory therapies that can reduce the cardiac muscle dysfunction of heart failure. One-time radiation therapyappears to persistently change cardiomyocyte behavior via altered epigenetic regulation of notch signaling, leading to modestly improved heart tissue function. Perhaps this should be taken as supportive of efforts to more directly target this regulatory pathway in...
by University of Birmingham Credit: Unsplash/CC0 Public Domain Researchers at the University of Birmingham have developed a new way to identify patients with heart failure who will benefit from treatment with beta-blockers. Their study involved 15,669 patients with heart failure and reduced left ventricular ejection fraction (low function of the heart’s main pumping chamber), 12,823 of which were in normal heart rhythm...
by European Society of Cardiology Credit: Pixabay/CC0 Public Domain Staying well hydrated throughout life could reduce the risk of developing heart failure, according to research presented at ESC Congress 2021. “Our study suggests that maintaining good hydration can prevent or at least slow down the changes within the heart that lead to heart failure,” said study author Dr. Natalia...
by American Heart Association Credit: Unsplash/CC0 Public Domain Sarpogrelate, an antiplatelet medication, has potential as a new heart failure therapy and, according to researchers, could potentially decrease health care costs associated with cardiovascular disease, according to preliminary animal research presented at the American Heart Association’s Basic Cardiovascular Sciences Scientific Sessions 2021. Cardiac hypertrophy is the abnormal enlargement, or thickening, of...
by University of Utah Health Sciences Credit: CC0 Public Domain A protein that helps regulate calcium signaling within heart cells could play a key role in preventing chronic heart failure, according to an international study led by University of Utah Health scientists. The researchers say disruption in the signaling pathway for this protein, VDAC2, causes severe impairment of...
by Baylor College of Medicine A stained section of a pig heart was treated with the viral vector 33 days after injection. Credit: S. Liu et al., Science Translational Medicine (2021) Research at Baylor College of Medicine, the Texas Heart Institute, and collaborating institutions are moving a novel promising gene therapy to treat heart failure closer...
EUROPEAN SOCIETY OF CARDIOLOGY Sophia Antipolis – 28 June 2021: A study in more than 200,000 individuals has found that patients with heart failure are more likely to develop cancer compared to their peers without heart failure. The research is presented today at Heart Failure 2021, an online scientific congress of the European Society of Cardiology (ESC),1...
by University of Cambridge Credit: geralt Switching off a heart muscle protein could provide a new way for drugs to combat heart failure in people who’ve had a heart attack, according to research led by the University of Cambridge and published in the journal Nature. There is an unmet need to find drugs that can successfully improve the heart’s ability...
AMERICAN COLLEGE OF CARDIOLOGY Patients with both diabetes and heart failure who were treated with sotagliflozin, a novel investigational drug for diabetes, for a median of nine to 16 months experienced reductions of 22% to 43% in the risk of death or worsening heart failure compared with similar patients who were treated with a placebo....
by American College of Cardiology Credit: Unsplash/CC0 Public Domain Patients with heart failure with preserved ejection fraction who took the antifibrotic drug pirfenidone saw a significant reduction in a marker of heart muscles carring compared with patients who received a placebo, based on findings from an early-phase trial presented at the American College of Cardiology’s 70th...
