by University of Utah Health Sciences Credit: CC0 Public Domain A protein that helps regulate calcium signaling within heart cells could play a key role in preventing chronic heart failure, according to an international study led by University of Utah Health scientists. The researchers say disruption in the signaling pathway for this protein, VDAC2, causes severe impairment of...
by Baylor College of Medicine A stained section of a pig heart was treated with the viral vector 33 days after injection. Credit: S. Liu et al., Science Translational Medicine (2021) Research at Baylor College of Medicine, the Texas Heart Institute, and collaborating institutions are moving a novel promising gene therapy to treat heart failure closer...
EUROPEAN SOCIETY OF CARDIOLOGY Sophia Antipolis – 28 June 2021: A study in more than 200,000 individuals has found that patients with heart failure are more likely to develop cancer compared to their peers without heart failure. The research is presented today at Heart Failure 2021, an online scientific congress of the European Society of Cardiology (ESC),1...
by University of Cambridge Credit: geralt Switching off a heart muscle protein could provide a new way for drugs to combat heart failure in people who’ve had a heart attack, according to research led by the University of Cambridge and published in the journal Nature. There is an unmet need to find drugs that can successfully improve the heart’s ability...
AMERICAN COLLEGE OF CARDIOLOGY Patients with both diabetes and heart failure who were treated with sotagliflozin, a novel investigational drug for diabetes, for a median of nine to 16 months experienced reductions of 22% to 43% in the risk of death or worsening heart failure compared with similar patients who were treated with a placebo....
by American College of Cardiology Credit: Unsplash/CC0 Public Domain Patients with heart failure with preserved ejection fraction who took the antifibrotic drug pirfenidone saw a significant reduction in a marker of heart muscles carring compared with patients who received a placebo, based on findings from an early-phase trial presented at the American College of Cardiology’s 70th...
JOHNS HOPKINS MEDICINE Clinicians and scientists have long observed that cells in overstressed hearts have high levels of the simple sugar O-GlcNAc modifying thousands of proteins within cells. Now, researchers at Johns Hopkins Medicine have found evidence in mouse experiments that these excess sugars could well be a cause, not merely a consequence or marker of heart...
AMERICAN COLLEGE OF CARDIOLOGY Breathing in secondhand cigarette smoke may leave you more vulnerable to heart failure, a condition where the heart isn’t pumping as well as it should and has a hard time meeting the body’s needs, according to a study being presented at the American College of Cardiology’s 70th Annual Scientific Session. The...
Researchers at Penn Medicine uncover more genetic mutations that predispose women to peripartum cardiomyopathy, with implications for the future of increased genetic testing. Researchers at Penn Medicine have identified more genetic mutations that strongly predispose younger, otherwise healthy women to peripartum cardiomyopathy (PPCM), a rare condition characterized by weakness of the heart muscle that begins sometime during...
For a while now, heart disease researchers have known that a protein called GRK5 – expressed throughout the body, though most notably in the lungs, heart, and placenta – normally dwells in the outer membrane of heart cells and, upon exposure to stress, moves into the cell nucleus, switching on a host of genes that lead to cardiomyopathy (thickening...
