JOHNS HOPKINS MEDICINE Clinicians and scientists have long observed that cells in overstressed hearts have high levels of the simple sugar O-GlcNAc modifying thousands of proteins within cells. Now, researchers at Johns Hopkins Medicine have found evidence in mouse experiments that these excess sugars could well be a cause, not merely a consequence or marker of heart...
Tag: <span>heart failure</span>
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Secondhand smoke linked to higher odds of heart failure
AMERICAN COLLEGE OF CARDIOLOGY Breathing in secondhand cigarette smoke may leave you more vulnerable to heart failure, a condition where the heart isn’t pumping as well as it should and has a hard time meeting the body’s needs, according to a study being presented at the American College of Cardiology’s 70th Annual Scientific Session. The...
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Study Helps Unravel Why Young, Pregnant Women Develop Heart Failure Similar to That of Older Patients
Researchers at Penn Medicine uncover more genetic mutations that predispose women to peripartum cardiomyopathy, with implications for the future of increased genetic testing. Researchers at Penn Medicine have identified more genetic mutations that strongly predispose younger, otherwise healthy women to peripartum cardiomyopathy (PPCM), a rare condition characterized by weakness of the heart muscle that begins sometime during...
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Peptide ‘Trojan Horse’ Shows Promise in Preventing Heart Failure
For a while now, heart disease researchers have known that a protein called GRK5 – expressed throughout the body, though most notably in the lungs, heart, and placenta – normally dwells in the outer membrane of heart cells and, upon exposure to stress, moves into the cell nucleus, switching on a host of genes that lead to cardiomyopathy (thickening...
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Existing heart failure drug may treat potential COVID-19 long-hauler symptom
by University of California – San Diego 3D print of a spike protein of SARS-CoV-2, the virus that causes COVID-19–in front of a 3D print of a SARS-CoV-2 virus particle. The spike protein (foreground) enables the virus to enter and infect human cells. On the virus model, the virus surface (blue) is covered with spike proteins...
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Iron release may contribute to cell death in heart failure
ELIFE A process that releases iron in response to stress may contribute to heart failure, and blocking this process could be a way of protecting the heart, suggests a study in mice published today in eLife. People with heart failure often have an iron deficiency, leading some scientists to suspect that problems with iron processing in...
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Opportunities to better detect, manage and treat patients with undiagnosed atrial fibrillation
by Boston University School of Medicine Credit: Pixabay/CC0 Public Domain Atrial fibrillation (AF) is associated with a higher risk of complications including ischemic stroke, cognitive decline, heart failure, myocardial infarction and death. AF frequently is undetected until complications such as stroke or heart failure occur. While the public and clinicians have an intense interest in detecting AF earlier,...
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Temple researchers identify cardiac protein that causes different types of heart failure
TEMPLE UNIVERSITY HEALTH SYSTEM (Philadelphia, PA) – Like a failing fuel pump that causes a loss of engine power in a car, a diseased heart can take a serious toll on the body’s performance. For some patients, tasks like walking up a flight of stairs or walking across a room eventually turn into exhausting endeavors....
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Obesity weakens heart muscle in patients with a common type of heart failure
by Johns Hopkins University School of Medicine Two hearts, a normal on the left and one with heart failure with preserved ejection fraction (HFpEF) on the right. The heart with HFpEF has a thicker, stiffer left ventricular wall and therefore, less room in the ventricle chamber to fill with an adequate amount of blood to be...
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Intravenous iron reduced rehospitalization risk in people with heart failure
AMERICAN HEART ASSOCIATION DALLAS, Nov. 13, 2020 — Patients who were hospitalized with acute heart failure and had iron deficiency were less likely to return to the hospital if given intravenous iron replacement, according to late-breaking research presented today at the American Heart Association’s Scientific Sessions 2020. The virtual meeting is Friday, November 13 – Tuesday, November...