by St. Anna Children’s Cancer Research Institute Credit: CC0 Public Domain The immune system is one of the most complex and fascinating networks in the human body. Comprised of cellular and humoral components, it not only protects us against external intruders such as viruses or bacteria, but also plays a fundamental role in detecting aberrant...
Acute myeloid leukemia (AML) is a hematological malignancy which incidence increases with age, that is biologically, phenotypically, and genetically very heterogeneous. Its treatment uses to combine chemotherapy followed by allogenic Hematopoietic Stem and Progenitor Cells transplant (allo-HSCT), based on the patient’s eligibility, to consolidate complete remission and prevent relapse. Yet, except for a few subgroups,...
A good vitamin D status is beneficial both in cancer prevention and in the prognosis of several cancers, according to a new research review. The anti-cancer effects of vitamin D are especially pronounced in the prevention and treatment of colon cancer and blood cancers. In addition, high vitamin D responsiveness can be linked to a...
OSAKA UNIVERSITY A group of researchers at Osaka University revealed that ESAM (Endothelial cell-selective adhesion molecule), a surface marker for hematopoietic stem cells (HSCs) and vascular endothelial cells (ECs), played an important role in the ontogeny of hematopoiesis in mice, particularly in the development of adult-type erythropoiesis. Their research results were published in Stem Cell...
Researchers at Osaka University reveal how a regulatory molecule ensures an appropriate supply of blood cells while avoiding the excessive proliferation associated with conditions like leukemia OSAKA UNIVERSITY Osaka, Japan – The body needs to create a continuous supply of blood cells to enter circulation. Blood cells have a wide variety of functions ranging from supplying oxygen to tissues, fighting infections, and enabling the blood to...
