TOKYO METROPOLITAN INSTITUTE OF MEDICAL SCIENCE IMAGE: RAPID AND EXTENSIVE SCHWANN CELL DEATH UNDER HIGH-GLUCOSE PYRUVATE-DEPLETED CONDITIONS CAN BE EVOKED BY THE FOLLOWING SEQUENTIAL METABOLIC ALTERATIONS; 1) DIMINISHED TCA CYCLE INTERMEDIATES AND MITOCHONDRIAL ATP PRODUCTION, 2) REDUCED GAPDH ACTIVITY AND INHIBITION OF GLYCOLYTIC FLUX THROUGH THE ACTIVATION OF PARP, 3) ESCALATION OF THE POLYOL AND...
