by McMaster University Illustration of bacteria in the human gut. Credit: Darryl Leja, National Human Genome Research Institute, National Institutes of Health Researchers from McMaster University and Queen’s University have discovered a gut bacterial “super-producer” of histamine that can cause pain flare-ups in some patients with irritable bowel syndrome (IBS). The culprit is what has now...
by Bob Yirka , Medical Xpress In an interventional RCT, the role of histamine H1/H2 receptor signaling for exercise training adaptations was investigated. By chronic blockade of histamine H1/H2 receptors in humans, we show that integrative adaptations related to insulin sensitivity, vascular function and aerobic capacity are dependent on histamine signaling. Credit: Wim Derave A...
by University of Tsukuba Chronic kidney disease and heart failure are critical medical problems worldwide, and are closely associated in a phenomenon known as “cardiorenal syndrome.” The relationship between kidney dysfunction and heart dysfunction is complex. Many studies have attempted to understand this relationship; few have provided a clear target for treatment of the combined...
The activity of neurons in the striatum are regulated by neurotransmitter histamine and is associated with Tourette-like grooming behavior in mice. Yale scientists produced increased grooming behavior in mice that may model tics in Tourette syndrome and discovered these behaviors vanish when histamine—a neurotransmitter most commonly associated with allergies—is introduced into their brains. The...
