You know mRNA, now meet siRNAPeer-Reviewed Publication UNIVERSITY OF WATERLOO Society learned about the value of mRNA during the COVID-19 pandemic when we saw scientists and medical professionals harness its power to deliver a vaccine for the virus within a year. Now, University of Waterloo pharmacy associate professor Emmanuel Ho has developed a novel nanomedicine...
Tag: <span>HIV</span>
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HIV: Early treatment is one key to remission
by Pasteur Institute The anti-SIV antibody levels after treatment interruption are associated with the magnitude of antigen stimulation. Kinetics of plasma anti-gp140 SIV IgG (A) and IgA (E) in W4-treated and W24-treated CyMs. Comparison of anti-gp140 SIV IgG (B) and IgA (F) levels between W4- and W24-treated CyMs at baseline, on day 28 p.i.; at 6...
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HIV antibodies protect animals in proof-of-concept study
by National Institutes of Health Transmission electron micrograph of HIV-1 virus particles (red) budding and replicating from a segment of a chronically infected H9 cell (blue). Particles are in various stages of maturity; arc/semi-circles are immature particles that have started to form but are still part of the cell. Immature particles slowly change morphology into mat....
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Scientists invent single rapid test for both HIV and TB
by Tulane University Credit: Pixabay/CC0 Public Domain Researchers at Tulane have developed a new and rapid test that can detect both HIV and tuberculosis at the same time with just a small amount of blood. In a paper published in Clinical Chemistry, researchers led by Tony Hu, Weatherhead Presidential Chair in Biotechnology Innovation and director of...
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FDA approves treatment for multi-drug resistant HIV
by Viviana Sofía Flores Rivera, Yale University Credit: Pixabay/CC0 Public DomainLenacapavir, an injection, has been approved by the FDA for multi-drug resistant HIV. HIV is not curable yet, but it can be treated successfully throughout someone’s lifespan. “And so, in the field, we want to ensure that the treatments we have—which for now are for...
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Meningitis cases rising among gay men with HIV
by Alan Mozes Meningococcal disease—which includes meningitis—appears to be on the rise among Americans infected with HIV, new research reveals. Researchers stress that the risk to any one person remains exceedingly rare, regardless of their HIV status. Each year between 2017 and 2021 HIV-positive patients accounted for five to 15 cases of the bacterial disease,...
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Researchers identify protein that helps HIV remain silent
by Bruno Geoffroy, University of Montreal Throughout the course of antiretroviral therapy, HIV hides quietly in reservoirs inside CD4+ T lymphocytes, white blood cells that play a role in activating the immune system against infection. The existence of these viral sanctuaries explains why antiretroviral therapy has to be maintained throughout a patient’s lifetime in order to keep the virus...
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HIV, hepatitis B and hepatitis C can be detected from a single drop of blood, study shows
by European Society of Clinical Microbiology and Infectious Diseases Credit: Pixabay/CC0 Public Domain Data on a test that can detect HIV, hepatitis B and hepatitis C from a single drop of blood is being presented at this year’s European Congress of Clinical Microbiology & Infectious Diseases (ECCMID) in Copenhagen, Denmark, (April 15–18). More than one million people...
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A readily available dietary supplement may reverse organ damage caused by HIV and antiretroviral therapy
by Enrique Rivero, University of California, Los Angeles HIV infected T-cell. Credit: NIAID MitoQ, a mitochondrial antioxidant that is available to the public as a diet supplement, was found in a mouse study to reverse the detrimental effects that HIV and antiretroviral therapy (ART) have on mitochondria in the brain, heart, aorta, lungs, kidney and...
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Scientists shine a spotlight on yet another shrewd maneuver HIV uses to commandeer human cells
by Delthia Ricks, Medical Xpress Nef induces Btk autophosphorylation at Tyr551 in the activation loop. Each kinase reaction was performed with Btk alone or in presence of HIV‐1 Nef wild‐type (WT), the PxxP to AxxA mutant (2PA), SIV Nef, or wild‐type Nef plus 1 µM ibrutinib as a negative control. Aliquots collected at 0, 30, 60,...