Reviewed by Danielle Ellis, B.Sc. ViiV Healthcare, the global specialist HIV company majority owned by GlaxoSmithKline plc (“GSK”), with Pfizer Inc. and Shionogi Limited as shareholders, is pleased to announce that eligible people living with Human Immunodeficiency Virus (HIV) in England and Wales will soon have routine access to Vocabria (cabotegravir long-acting injection) developed by ViiV...
Tag: <span>HIV</span>
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Scientists discover sugar molecule on HIV-infected cell plays role in evading immune system
by The Wistar Institute HIV-1 Virus. Credit: J Roberto Trujillo/Wikipedia A new study by researchers at The Wistar Institute, an international biomedical research leader in cancer, immunology, infectious disease, and vaccine development, shows how key features on the surface of HIV-infected cells help the disease evade detection by the immune system. It also shows how these...
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A page from the COVID therapy playbook: Unleashing a flood of neutralizing antibodies against HIV
by Delthia Ricks , Medical Xpress A combination of the broadly neutralizing antibodies (bNAbs) and antibodies against the integrin reduced B cell follicles aggregates (brown spots) more than the bNAbs alone. Credit: I Frank et al., Science Translational Medicine (2021) For more than 40 years a goal that too often has proved elusive is a pharmaceutical defeat...
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Metabolic restoration in HIV-infected patients as a therapeutic approach
by Institut national de la recherche scientifique – INRS Microscopic image of an HIV-infected T cell. Credit: NIAID The human immunodeficiency virus (HIV-1) particularly attacks CD4 lymphocytes, a type of white blood cell considered to be the conductor of the immune system. Hamza Loucif, a doctoral student in virology and immunology, and Julien van Grevenynghe,...
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Solving mystery of rare cancers directly caused by HIV
by University of Pittsburgh John Mellors, M.D. Credit: UPMC For nearly a decade, scientists have known that HIV integrates itself into genes in cells that have the potential to cause cancer. And when this happens in animals with other retroviruses, those animals often develop cancer. But, perplexingly and fortunately, that isn’t regularly happening in people living...
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A novel method to block HIV in mice
by Griffith University Fig. 1: Screening of potent repressors of HIV-1 derived from fusion of ZFP362 and combination of repressor domains. a Schematic representation of the design of the ZD3A constructs leading to ZD3A protein. The NLS containing the ZFP362 domain can bind HIV-1 LTR promoter specifically and DNMT3A can recruit epigenetic silencing complexes. The binding...
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HIV linked with increased risk of sudden cardiac death
by American Heart Association Credit: CC0 Public Domain People living with human immunodeficiency virus (HIV) have a higher risk of sudden cardiac death than people who do not have HIV, especially if the virus is not well-controlled or if they have other heart disease risk factors, according to new research published today in the Journal of the American Heart...
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Is it possible to deliver a knockout punch to HIV?
by Delthia Ricks , Medical Xpress HIV infecting a human cell. Credit: NIH With a global focus on strategies to curb the expansion of a fast-moving coronavirus pandemic, the question again has arisen: What more is being done about HIV, a scourge that has lasted more than 40 years—is a cure finally in sight? Although...
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HIV has detrimental effect on children’s growth and bone strength
by University of Bristol An IMVASK (IMpact of Vertical HIV infection on child and Adolescent Skeletal development) clinic in Harare. Credit: Cynthia Mukwasi-Kahari, Harare Children growing up with HIV infection have concerning deficits in skeletal strength which become more apparent towards the end of pubertal growth, finds the largest study to date to investigate the link...
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People with HIV are at higher risk of ageing-related genetic changes
by University of New South Wales The question of how HIV affects the aging process is becoming an increasingly important field of research. Credit: Shutterstock We don’t know enough about biological processes in people who are aging with HIV—a new study sheds light on the matter. Forty years after the first diagnosis of HIV/AIDS, Australian scientists...