by University of Iowa β-Blocker Use in Participants With Motor-Manifest Huntington Disease (mmHD) Was Associated With Slower Rate of Symptom Progression. Credit: JAMA Neurology (2024). DOI: 10.1001/jamaneurol.2024.4108 A common heart drug may slow the progression of Huntington’s disease (HD), according to a new study by University of Iowa Health Care researchers. Using clinical information from a large, observational...
Tag: <span>Huntington disease</span>
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Huntington’s disease gene may also enhance early brain development and intelligence
by Jennifer Brown, University of Iowa Years-to-onset (YTO)-dependent brain functional changes. Credit: Annals of Neurology (2024). DOI: 10.1002/ana.27046 The genetic mutation that causes Huntington’s disease (HD)—a devastating brain disease that disrupts mobility and diminishes cognitive ability—may also enhance early brain development and play a role in promoting human intelligence. This revelation comes from more than 10 years of...
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Discovery of key mechanism in Huntington’s disease could pave the way for early detection and treatment
by University of Oxford TrkbPenk-KO mice develop hyperactivity following DA increase. Credit: Nature Metabolism (2024). DOI: 10.1038/s42255-024-01155-z Researchers from the University of Oxford have identified a key biochemical mechanism relevant to the development of Huntington’s disease. This discovery opens up the possibility of studying the disease before its clinical onset and eventually stopping its progression. The study, published in Nature Metabolism, has shown...
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Researchers discover what hinders DNA repair in patients with Huntington disease
September 27, 2024 by McMaster University A montage of three images of single striatal neurons transfected with a disease-associated version of huntingtin, the protein that causes Huntington’s disease. Nuclei of untransfected neurons are seen in the background (blue). The neuron in the center (yellow) contains an abnormal intracellular accumulation of huntingtin called an inclusion body...