by IOS Press In clinical trials of adults with Huntington’s disease (HD) the Q-Suite Motor Assessment Tool (Q-Motor) has proven to be helpful to detect and quantitate subtle motor abnormalities. With the anticipated arrival of preventive gene therapies that will most likely be administered to young children known to be carriers of the HD mutation,...
Tag: <span>Huntington’s Disease</span>
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The activity of disease allele-selective zinc finger proteins in preclinical models of Huntington’s disease
by Sangamo Therapeutics, Inc. Sangamo Therapeutics, Inc., a genomic medicine company, today announced the publication of a manuscript describing the activity of allele-selective zinc finger protein transcription-factors (ZFP-TFs) in preclinical models of Huntington’s disease (HD). The data were published online on July 1 and will appear in the July 2019 issue of Nature Medicine. The...
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Searching for the origins of the depressive symptoms in Huntington’s disease
Cdk5 Kinase: An essential protein UNIVERSITY OF BARCELONA About 40% of the affected patients with Huntington’s disease -a neurodegenerative pathology- show depression symptoms, even in early stages before the apparition of the typical motor symptoms of the disease. An altered function of Cdk5 kinase -an essential enzyme in several cell signalling pathways- could explain the physiopathology of the depressive-like behaviour in Huntington’s disease, according to...
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Circadian clock plays unexpected role in neurodegenerative diseases
by Northwestern University While your body might bemoan the many uncomfortable effects of jet lag, your brain may be thanking you for that cross-time zone travel. In a new study, Northwestern University researchers induced jet lag in a fruit fly model of Huntington disease and found that jet lag protected the flies’ neurons. The team then...
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Predicting the onset and course of Huntington’s disease
An MDC research team reports in the journal Molecular Cell that short protein fibers precede the formation of larger deposits that accumulate in the brains of those affected by the incurable Huntington’s disease, sometimes called Huntington’s chorea. These results could improve diagnosis and aid the search for new medications. Microscopic image of a fly’s brain. The huntingtin deposits that...
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Powerful molecules provide new findings about Huntington’s disease
LUND UNIVERSITY Researchers at Lund University in Sweden have discovered a direct link between the protein aggregation in nerve cells that is typical for neurodegenerative diseases, and the regulation of gene expression in Huntington’s disease. The results pave the way for the development of new treatment strategies for diseases that involve impairment of the basic mechanism...
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Huntington’s disease—how brain training games could help
July 9, 2018 by Emma Yhnell, The Conversation In the search for new treatments, science often focuses on medication first. But drugs aren’t the only way to fight illness, particularly when looking at brain diseases. My research looks into how playing specially designed computer games might help people who are living with Huntington’s disease. Huntington’s is a brain disorder that gets...
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Huntington’s breakthrough may stop disease
The defect that causes the neurodegenerative disease Huntington’s has been corrected in patients for the first time, the BBC has learned. An experimental drug, injected into spinal fluid, safely lowered levels of toxic proteins in the brain. The research team, at University College London, say there is now hope the deadly disease can be stopped. Experts...
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Existing cancer medication offers potential to treat Huntington’s disease
A drug already used to treat certain forms of cancer may also be an effective therapy for Huntington’s disease, according to a new study in the latest issue of Science Translational Medicine. The same study also increases our understanding of how this drug, and other medications like it, may offer hope for other neurodegenerative diseases like...
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Huntington’s Disease: Researcher Discover A Way To Stop Progression Of The Fatal Disease
Huntington’s disease is a neurodegenerative disorder, which mostly affects middle-aged people. It is a genetic disorder and affects muscle co-ordination, which eventually progresses into dementia. Scientists have been unable to find a cure for the fatal brain disease. However, a new study may be the light at the end of the tunnel and may have...