by Texas Heart Institute Design of injectable hydrogel electrode. Redox initiation reaction of polyether urethane diacrylamide (PEUDAm) macromer + N-acryloyl glycinamide (NAGA) delivered using double barrel syringe with a mixing head. Ammonium persulfate (APS) and iron gluconate (IG) are used as initiator and reducing agents. Resulting hydrogels display bidentate hydrogen bonding at netpoints for improved...
Tag: <span>hydrogel</span>
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Revolutionary Seaweed and Carbonated Water Based Hydrogel for Treating Skin Wounds
Acting as the main interface between the internal and the external world, the skin is the largest and most important organ of the human body. It is frequently exposed to many types of physical injuries or wounds, including cuts, scrapes, scratches, infections, and ulcers.Unfortunately, as one ages, the skin becomes more frail and less capable...
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Novel hydrogel finds new aptamers, or ‘chemical antibodies,’ in days
by Tim Schley, Pennsylvania State University A new method for selecting aptamers, or ‘chemical antibodies,’ created by Penn State engineers takes only days to complete, instead of the months typically needed for traditional methods. Credit: Kate Myers/Penn StateOne double-helix strand of DNA could extend six feet, but it is so tightly coiled that it packs an...
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Single-dose injectable nanovaccine-in-hydrogel for robust cancer immunotherapy
by Thamarasee Jeewandara , Medical Xpress In situ vaccination with single-dose NvIH reduced TME immunosuppression, enhanced TME antitumor immune milieu, and elicited systemic antitumor immunity, resulting in robust immunotherapy of large poorly immunogenic tumors with abscopal effect. NvIH is composed of injectable (NVs + ICBs)-in-hydrogel that was loaded with triple immunostimulants (TLR7/8/9 and STING agonists...
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Hydrogel designed to remove every bit of those “blasted” kidney stones
By Ben Coxworth April 04, 2022 Purenum founders Prof. Ingo Grunwald (left) and Manfred PeschkaPurenum GmbH Although some kidney stones can be treated with medication, larger ones are often broken up with an endoscopic laser. A new hydrogel is now claimed to be capable of removing even the smallest of the resulting fragments, instead of...
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A new injectable hydrogel for cartilage repair
by Bob Yirka , Medical Xpress Credit: Pixabay/CC0 Public Domain A team of researchers affiliated with a host of institutions in China has developed an injectable hydrogel for use in repairing damaged cartilage. In their paper published in the journal Science Advances, the group describes how they made their hydrogel, how it can be applied and how well...
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Oxygen-delivering hydrogel accelerates diabetic wound healing
About one-fourth of people with diabetes develop painful foot ulcers, which are slow to heal due to low oxygen in the wound from impaired blood vessels and increased inflammation. These wounds can become chronic, leading to poor quality of life and potential amputation. Representative images of wounds treated with or without gel and oxygen-release microspheres...
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New hydrogel that cuts in half recovery time from muscle injuries
UNIVERSITAT POLITÈCNICA DE VALÈNCIA IMAGE: PATRICIA RICO AND ANA RODRÍGUEZ (UPV-CIBERBBN) CREDIT: UPV A team from the Universitat Politècnica de València (UPV) and the CIBER Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN) has designed and tested, at a preclinical level, a new biomaterial for the treatment and recovery of muscle injuries. It is a boron-loaded alginate hydrogel,...
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Uprooting cancer: Hydrogel rapidly reverts cancer cells back to cancer stem cells
HOKKAIDO UNIVERSITY A hydrogel, a type of soft matter, developed at Hokkaido University successfully reverted cancer cells back to cancer stem cells within 24 hours, in six different human cancer types. This could lead to the development of anti-cancer stem cell drugs and personalized medicines. An innovative hydrogel – called a double network (DN) gel...
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Injectable hydrogel could someday lead to more effective vaccines
AMERICAN CHEMICAL SOCIETY Vaccines have curtailed the spread of several infectious diseases, such as smallpox, polio and measles. However, vaccines against some diseases, including HIV-1, influenza and malaria, don’t work very well, and one reason could be the timing of antigen and adjuvant presentation to the immune system. Now, researchers reporting in ACS Central Sciencedeveloped an...