Adults with hypersensitivity pneumonitis (HP) expressed interest in more knowledge of prognosis, etiology, treatment, and living well with the disease, based on new survey data presented at the American Thoracic Society International Conference. HP is caused by environmental exposure and is often incurable, and patients are challenged with identifying and mitigating the exposure with limited...
Tag: <span>hypersensitivity</span>
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Boosting certain brain cells diminishes hypersensitivity in Fragile X mice
by University of California, Los Angeles Credit: Pixabay/CC0 Public Domain Boosting the activity of inhibitory interneurons in Fragile X mice reduced their hypersensitivity to sensory stimuli, according to a new Neuron study led by UCLA Health researchers. Fragile X Syndrome, which is caused by a mutation in a single gene, is the most common inherited form of intellectual disability...
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Activation of microglia in the spinal cord after nerve injury found to contribute to pain hypersensitivity
by Bob Yirka , Medical Xpress A perineuronal net surrounding a projection neuron in the spinal cord and depicts microglia digesting the net. Degradation of the perineuronal net by microglia causes increased neuronal activity and pain. Credit: Designs that Cell A team of researchers working at McGill University has found that activation of microglia in...
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Dartmouth-led team engineers new treatment for drug-resistant bacterial infections
THAYER SCHOOL OF ENGINEERING AT DARTMOUTH A MOLECULAR MODEL OF THE F12 BIOTHERAPY SHOWS THE FOLD OF ITS POLYPEPTIDE BACKBONE. RESIDUAL T CELL EPITOPES ARE MAPPED ONTO THE STRUCTURE AND COLORED FROM WHITE (NO EPITOPES). The Centers for Disease Control and Prevention (CDC) has prioritized finding effective treatment of Methicillin-resistant Staphylococcus aureus (MRSA), one of...
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International team of scientists discover link between genes and penicillin allergy using
International team of scientists discover link between genes and penicillin allergy using biobanks from Estonia, UK and USA Penicillin, a life-saving medicine, is the most common cause of drug allergy, with clinical manifestations ranging from temporary skin reactions to life-threatening systemic syndromes. Thus far, genetic factors have only been found for rare severe allergic reactions...
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New clues to lung-scarring disease may aid treatment
by Vanderbilt University Medical Center Scientists at Vanderbilt University Medical Center (VUMC) and the Translational Genomics Research Institute (TGen) in Phoenix, Arizona, have discovered previously unreported genetic and cellular changes that occur in the lungs of people with pulmonary fibrosis (PF). Their findings, reported Wednesday, July 8, in the journal Science Advances, should aid the...
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In mouse study, black raspberries show promise for reducing skin inflammation
by Laura Arenschield, The Ohio State University Eating black raspberries might reduce inflammation associated with skin allergies, a new study indicates. In a study done with mice and published earlier this month in the journal Nutrients, researchers found that a diet high in black raspberries reduced inflammation from contact hypersensitivity—a condition that causes redness and...
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Drug combination reverses hypersensitivity to noise in a model of autism spectrum disorder
by Anne Trafton, Massachusetts Institute of Technology People with autism often experience hypersensitivity to noise and other sensory input. MIT neuroscientists have now identified two brain circuits that help tune out distracting sensory information, and they have found a way to reverse noise hypersensitivity in mice by boosting the activity of those circuits. One of the circuits the researchers identified is involved in filtering noise, while the...
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Inflammation amps up neurite growth, gene expression involved in heat, cold sensitivity
by Tracey Peake, North Carolina State University Researchers from North Carolina State University have found that inflammation increases neuronal activity, gene expression and sensory nerve (neurite) outgrowth in neurons involved in thermal—but not physical- sensations in mice. The work sheds light on the role that inflammation-induced over expression of calcium channel genes may play in...
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FDA approves first drug to help tame cluster headaches
Episodic cluster headaches are “an extremely painful and often debilitating condition,” the FDA’s Dr. Eric Bastings noted in an agency news release. He’s deputy director of the Division of Neurology Products in the FDA’s Center for Drug Evaluation and Research. Cluster headaches occur in quick sequence, “often at the same time(s) of the day, for several weeks...
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