by University of Liverpool Induced autophagy by rilmenidine perturbed polyQ aggregation. (a) Representative images of day 2 adult transgenic animals, expressing the intestinal specific autophagy reporter gene Pnhx-2::mCherry::lgg-1 showing increased autophagy, when exposed to varying concentrations of rilmenidine for 24 h compared to 1% DMSO vehicle. Arrows indicate autophagosome puncta formation. Scale bar = 20 μm. (b)...
COLUMBIA UNIVERSITY IRVING MEDICAL CENTER Chlorthalidone, the guideline-recommended diuretic for lowering blood pressure, causes more serious side effects than hydrochlorothiazide, a similarly effective diuretic, according to a new study led by researchers at Columbia University Irving Medical Center. The findings, published in JAMA Internal Medicine, contrast with current treatment guidelines recommending chlorthalidone over hydrochlorothiazide. The...
