A protein with a role in sensing cell damage and viral infections is a new target for the treatment of pulmonary hypertension, or increased blood pressure in the lungs, according to research led by Virginia Commonwealth University and the University of Sheffield in the United Kingdom. The disease can lead to heart failure because the heart must...
Tag: <span>Hypertension</span>
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Investigational urate elevation does not appear to raise hypertension risk
Both phase 2 clinical trial results and animal model studies find no association between urate manipulation and blood pressure MASSACHUSETTS GENERAL HOSPITAL A study from a group of Massachusetts General Hospital (MGH) investigators may reduce the concern that elevated levels of urate, an approach being investigated to treat several neurodegenerative disorders, could increase the risk...
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Diagnosing and treating resistant hypertension
Resistant hypertension affects 12 percent to 15 percent of patients treated for high blood pressure according to a new scientific statement from the American Heart Association. The statement, published in the Association’s journal Hypertension, provides a comprehensive overview of how to diagnose and treat the condition based on a review of available scientific information. Credit: CC0...
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Gout drug reduces adverse events in patients with hyperuricaemia
Munich, Germany – 28 Aug 2018: Uric acid reduction with the gout treatment febuxostat reduces adverse events in elderly patients with hyperuricaemia, according to late breaking researchpresented today in a Hot Line Session at ESC Congress 2018. IMAGE: KAPLAN-MEIER CURVES FOR THE PRIMARY COMPOSITE EVENT. Hyperuricaemia, an abnormally high serum uric acid level, causes gout and is...
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Analysis: Commonly used drugs are rarely studied in primary care patients
Drugs most commonly prescribed to patients seen by primary care physicians are not often tested in the patients who go to these clinics, where most people receive their care, say investigators at Georgetown University Medical Center (GUMC) and Yale School of Medicine. The study, published in the September edition of Journal of General Internal Medicine, looked...
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Antioxidant found to wind back the clock on blood vessel function by up to 20 years
Much mystery surrounds the physiological processes by which humans age, but scientists are learning more all the time. With this knowledge come new possibilities around how we can not only slow them down, but possibly even reverse them. A new breakthrough at the University of Colorado is the latest advance in the area, demonstrating how a chemically...
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Johns Hopkins investigators unravel biological roots of pulmonary hypertension
Working with cells that line the innermost layer of the blood vessels, Johns Hopkins investigators say they have made a leap forward in understanding the underlying biology behind pulmonary hypertension, a dangerous type of high blood pressure in lungs that ultimately leads to right heart failure and death. By conducting experiments in endothelial cells, they discovered...
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Boosting enzyme may help improve blood flow, fitness in elderly
An enzyme called SIRT1 declines in the blood vessels with age and restoring it reverses the effects of vascular aging. After receiving a supplement called NMN, older mice showed increased capillary density, blood flow, mobility, and …more As people age, their blood-vessel density and blood flow decrease, which is why it’s harder to maintain muscle...